Matches in SemOpenAlex for { <https://semopenalex.org/work/W2583090451> ?p ?o ?g. }
- W2583090451 abstract "Introduction Despite its in vitro efficacy, penicillin often fails to eradicate Group A β-hemolytic streptococci (GABHS) from patients with acute and relapsing pharyngo- tonsillitis (PT). Objective This review of the literature details the causes of penicillin failure to eradicate GABHS PT and the therapeutic modalities to reduce and overcome antimicro- bial failure. Data Synthesis The causes of penicillin failure in eradicating GABHS PT include the presence of β lactamase producing bacteria (BLPB) that protect GABHS from any penicillin; the absence of bacteria that interfere with the growth of GABHS; co- aggregation between GABHS and Moraxella catarrhalis; and the poor penetration of penicillin into the tonsillar tissues and the tonsillo-pharyngeal cells, which allows intracellular GABHS and Staphylococcus aureus to survive. The inadequate intracellular penetration of penicillin can allow intracellular GABHS and S. aureus to persist. In the treatment of acute tonsillitis, the use of cephalosporin can overcome these interactions by eradicating aerobic BLPB (including M. catarrhalis), while preserving the potentially interfering organisms and eliminating GABHS. Conclusion In treatment of recurrent and chronic PT, the administration of clinda- mycin, or amoxicillin-clavulanic acid, can eradicate both aerobic and anaerobic BLPB, as well as GABHS. The superior intracellular penetration of cephalosporin and clindamycin also enhances their efficacy against intracellular GABHS and S. aureus." @default.
- W2583090451 created "2017-02-03" @default.
- W2583090451 creator A5072351755 @default.
- W2583090451 date "2016-01-01" @default.
- W2583090451 modified "2023-09-24" @default.
- W2583090451 title "Treatment Challenges of Group AB eta-hemolytic Streptococcal Pharyngo-Tonsillitis" @default.
- W2583090451 cites W140984475 @default.
- W2583090451 cites W1967650262 @default.
- W2583090451 cites W1970828234 @default.
- W2583090451 cites W1973080739 @default.
- W2583090451 cites W1973128630 @default.
- W2583090451 cites W1973451202 @default.
- W2583090451 cites W1976267090 @default.
- W2583090451 cites W1977091583 @default.
- W2583090451 cites W1977468108 @default.
- W2583090451 cites W1981656512 @default.
- W2583090451 cites W1985055480 @default.
- W2583090451 cites W1992406004 @default.
- W2583090451 cites W1995293528 @default.
- W2583090451 cites W1995716419 @default.
- W2583090451 cites W1997361285 @default.
- W2583090451 cites W2002226163 @default.
- W2583090451 cites W2006155853 @default.
- W2583090451 cites W2008083188 @default.
- W2583090451 cites W2008562258 @default.
- W2583090451 cites W2008932665 @default.
- W2583090451 cites W2014335701 @default.
- W2583090451 cites W2014994343 @default.
- W2583090451 cites W2020590799 @default.
- W2583090451 cites W2021921445 @default.
- W2583090451 cites W2023608851 @default.
- W2583090451 cites W2025838779 @default.
- W2583090451 cites W2029951854 @default.
- W2583090451 cites W2033185381 @default.
- W2583090451 cites W2037204664 @default.
- W2583090451 cites W2039101516 @default.
- W2583090451 cites W2042855670 @default.
- W2583090451 cites W2044449043 @default.
- W2583090451 cites W2048127896 @default.
- W2583090451 cites W2050560420 @default.
- W2583090451 cites W2055800719 @default.
- W2583090451 cites W2057631159 @default.
- W2583090451 cites W2057665563 @default.
- W2583090451 cites W2059871209 @default.
- W2583090451 cites W2060713566 @default.
- W2583090451 cites W2062958813 @default.
- W2583090451 cites W2065009077 @default.
- W2583090451 cites W2067823145 @default.
- W2583090451 cites W2076801253 @default.
- W2583090451 cites W2080283350 @default.
- W2583090451 cites W2081335407 @default.
- W2583090451 cites W2087231206 @default.
- W2583090451 cites W2090187008 @default.
- W2583090451 cites W2098808661 @default.
- W2583090451 cites W2100048220 @default.
- W2583090451 cites W2101857535 @default.
- W2583090451 cites W2102294971 @default.
- W2583090451 cites W2108115910 @default.
- W2583090451 cites W2111970213 @default.
- W2583090451 cites W2112413788 @default.
- W2583090451 cites W2112640413 @default.
- W2583090451 cites W2112798448 @default.
- W2583090451 cites W2118715408 @default.
- W2583090451 cites W2119764765 @default.
- W2583090451 cites W2119925402 @default.
- W2583090451 cites W2122448628 @default.
- W2583090451 cites W2125554811 @default.
- W2583090451 cites W2126522183 @default.
- W2583090451 cites W2126966789 @default.
- W2583090451 cites W2127886138 @default.
- W2583090451 cites W2132003892 @default.
- W2583090451 cites W2132865082 @default.
- W2583090451 cites W2132878960 @default.
- W2583090451 cites W2138375188 @default.
- W2583090451 cites W2138392585 @default.
- W2583090451 cites W2145878903 @default.
- W2583090451 cites W2146385460 @default.
- W2583090451 cites W2146602654 @default.
- W2583090451 cites W2148185525 @default.
- W2583090451 cites W2149512898 @default.
- W2583090451 cites W2152678474 @default.
- W2583090451 cites W2156132915 @default.
- W2583090451 cites W2156820527 @default.
- W2583090451 cites W2158939557 @default.
- W2583090451 cites W2160797478 @default.
- W2583090451 cites W2163904735 @default.
- W2583090451 cites W2164172927 @default.
- W2583090451 cites W2167624920 @default.
- W2583090451 cites W22933132 @default.
- W2583090451 cites W2399176332 @default.
- W2583090451 cites W2466586497 @default.
- W2583090451 cites W2768771379 @default.
- W2583090451 cites W54768759 @default.
- W2583090451 cites W98244175 @default.
- W2583090451 cites W2331726982 @default.
- W2583090451 cites W2468692136 @default.
- W2583090451 hasPublicationYear "2016" @default.
- W2583090451 type Work @default.
- W2583090451 sameAs 2583090451 @default.
- W2583090451 citedByCount "0" @default.