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- W2583118422 abstract "Background and Purpose: Sleep disorder breathing (SDB) is a risk factor for stroke, but little is known about the effect of airway titration pressure support on the outcome in stroke patients with SDB. The therapeutic value of airway titration in reducing new vascular events, death and disability remains unproven. We performed a meta-analysis to determine the effects of titration support on clinical and safety outcomes compared with best medical treatment.Subjects and Methods: Two reviewers independently abstracted and entered data into a structured dataset. Randomized and non randomized studies that compared airway titration treatment with best medical therapy in stroke patients were included. A total of 6 trials met the inclusion criteria and were included in the meta-analysis. We calculated pooled risk ratios and 95[percnt] CIs (confidence intervals) using random-effects models. Main outcome measure were new vascular events, mortality and improvement in modified Rankin scale (mRS).Results: Of the 546 total subjects, follow up for new vascular events was available in 341 patients. A total of 58 (18[percnt]) new vascular events occurred during the follow-up period. There was no difference between the risk of new vascular events between subjects who received airway titration therapy compared with those who received standard care (RR 0.59 CI 95[percnt] 0.21-1.69,p=0.32). Airway titration therapy was associated with lower likelihood of mortality in comparison to best medical therapy (RR 0.47 CI 95[percnt] 0.23-0.98, p=0.04). There was no difference between the improvement of mRS between airway titration therapy compared with those who received standard care (RR 1.26 CI 95[percnt] 0.72-2.18, p=0.42).Conclusion: Airway titration treatment was associated with lower likelihood of mortality in acute stroke patients with SDB. Disclosure: Dr. Tsivgoulis has nothing to disclose. Dr. Goyal has nothing to disclose. Dr. Ishfaq has nothing to disclose. Dr. Pandhi has nothing to disclose. Dr. Alexandrov has received personal compensation for activities with Genentech." @default.
- W2583118422 created "2017-02-10" @default.
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- W2583118422 date "2016-04-05" @default.
- W2583118422 modified "2023-09-23" @default.
- W2583118422 title "Effect of Airway Titration Treatment on Outcomes after Acute Stroke: A Meta-Analysis of Randomized and Non Randomized Studies (P2.277)" @default.
- W2583118422 hasPublicationYear "2016" @default.
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