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- W2583125957 abstract "Air pollution is associated with increased morbidity and mortality caused by respiratory and cardiovascular diseases; however, increasing evidence suggests that it may also negatively affect the brain and contribute to central nervous system (CNS) diseases. Air pollution is a mixture comprised of several components, including ambient particulate matter (PM), gases, organic compounds, and metals. A major contributor to ambient PM, particularly of ultrafine PM, is represented by traffic-related air pollution, in great part due to diesel exhaust. Human epidemiological studies and controlled animal experiments have shown that exposure to air pollution may lead to a variety of behavioral abnormalities. In addition, air pollution may contribute to the etiology of neurodevelopmental (e.g., autism) and neurodegenerative disorders (e.g., Alzheimer's disease). Findings in animals and humans indicate that air pollution increases expression of markers of neurodegenerative disease pathologies in brain. Oxidative stress and neuroinflammation are two cardinal effects of air pollution in the CNS and may be involved in the ability of air pollution to cause neurodegeneration. The strongest evidence so far relates to a possible contribution of air pollution to the etiology of Alzheimer's disease. Potential underlying mechanisms, such as alterations in adult neurogenesis, and disruption of reelin homeostasis, of miRNA expression, and of glutamate signaling, are discussed." @default.
- W2583125957 created "2017-02-10" @default.
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- W2583125957 date "2015-12-01" @default.
- W2583125957 modified "2023-09-27" @default.
- W2583125957 title "Letter to the Editor on “Exposure to hazardous air pollutants and the risk of amyotrophic lateral sclerosis”" @default.
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- W2583125957 doi "https://doi.org/10.1016/j.envpol.2015.03.007" @default.
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