FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2583133006> ?p ?o ?g. }

• W2583133006 endingPage "821.e9" @default.
• W2583133006 startingPage "806" @default.
• W2583133006 abstract "The current knowledge about heat nociception is mainly confined to the thermosensors, including the transient receptor potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG). However, the loss of thermosensors only partially impairs heat nociception, suggesting the existence of undiscovered mechanisms. We found that the loss of an intracellular fibroblast growth factor (FGF), FGF13, in the mouse DRG neurons selectively abolished heat nociception. The noxious heat stimuli could not evoke the sustained action potential firing in FGF13-deficient DRG neurons. Furthermore, FGF13 interacted with the sodium channel Nav1.7 in a heat-facilitated manner. FGF13 increased Nav1.7 sodium currents and maintained the membrane localization of Nav1.7 during noxious heat stimulation, enabling the sustained firing of action potentials. Disrupting the FGF13/Nav1.7 interaction reduced the heat-evoked action potential firing and nociceptive behavior. Thus, beyond the thermosensors, the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals." @default.
• W2583133006 created "2017-02-10" @default.
• W2583133006 creator A5008711004 @default.
• W2583133006 creator A5016909042 @default.
• W2583133006 creator A5020590496 @default.
• W2583133006 creator A5021639650 @default.
• W2583133006 creator A5024534843 @default.
• W2583133006 creator A5026222209 @default.
• W2583133006 creator A5031451451 @default.
• W2583133006 creator A5034821104 @default.
• W2583133006 creator A5035419929 @default.
• W2583133006 creator A5048957271 @default.
• W2583133006 creator A5057369590 @default.
• W2583133006 creator A5060706512 @default.
• W2583133006 creator A5067301497 @default.
• W2583133006 creator A5071781931 @default.
• W2583133006 creator A5074905444 @default.
• W2583133006 date "2017-02-01" @default.
• W2583133006 modified "2023-10-17" @default.
• W2583133006 title "FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7" @default.
• W2583133006 cites W1549160512 @default.
• W2583133006 cites W1602874868 @default.
• W2583133006 cites W163561699 @default.
• W2583133006 cites W1835398160 @default.
• W2583133006 cites W1864746282 @default.
• W2583133006 cites W1876630933 @default.
• W2583133006 cites W1967441802 @default.
• W2583133006 cites W1977198561 @default.
• W2583133006 cites W1982626347 @default.
• W2583133006 cites W1990800058 @default.
• W2583133006 cites W1991522466 @default.
• W2583133006 cites W1992381837 @default.
• W2583133006 cites W2000681405 @default.
• W2583133006 cites W2008943142 @default.
• W2583133006 cites W2012943391 @default.
• W2583133006 cites W2015249233 @default.
• W2583133006 cites W2015470781 @default.
• W2583133006 cites W2023718219 @default.
• W2583133006 cites W2024766841 @default.
• W2583133006 cites W2026551512 @default.
• W2583133006 cites W2026945534 @default.
• W2583133006 cites W2028369871 @default.
• W2583133006 cites W2031572683 @default.
• W2583133006 cites W2037355835 @default.
• W2583133006 cites W2037903288 @default.
• W2583133006 cites W2038397615 @default.
• W2583133006 cites W2038731679 @default.
• W2583133006 cites W2046486142 @default.
• W2583133006 cites W2046505703 @default.
• W2583133006 cites W2048508307 @default.
• W2583133006 cites W2050781058 @default.
• W2583133006 cites W2055184522 @default.
• W2583133006 cites W2066611127 @default.
• W2583133006 cites W2079521980 @default.
• W2583133006 cites W2082600118 @default.
• W2583133006 cites W2085332935 @default.
• W2583133006 cites W2098007639 @default.
• W2583133006 cites W2105668301 @default.
• W2583133006 cites W2106207830 @default.
• W2583133006 cites W2108114952 @default.
• W2583133006 cites W2130496291 @default.
• W2583133006 cites W2132856129 @default.
• W2583133006 cites W2134742719 @default.
• W2583133006 cites W2138809708 @default.
• W2583133006 cites W2145540995 @default.
• W2583133006 cites W2147865003 @default.
• W2583133006 cites W2149570279 @default.
• W2583133006 cites W2154397078 @default.
• W2583133006 cites W2155296569 @default.
• W2583133006 cites W2156289861 @default.
• W2583133006 cites W2157250445 @default.
• W2583133006 cites W2159332152 @default.
• W2583133006 cites W2171785121 @default.
• W2583133006 cites W2211603551 @default.
• W2583133006 cites W2257665898 @default.
• W2583133006 cites W2278844416 @default.
• W2583133006 doi "https://doi.org/10.1016/j.neuron.2017.01.009" @default.
• W2583133006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28162808" @default.
• W2583133006 hasPublicationYear "2017" @default.
• W2583133006 type Work @default.
• W2583133006 sameAs 2583133006 @default.
• W2583133006 citedByCount "53" @default.
• W2583133006 countsByYear W25831330062017 @default.
• W2583133006 countsByYear W25831330062018 @default.
• W2583133006 countsByYear W25831330062019 @default.
• W2583133006 countsByYear W25831330062020 @default.
• W2583133006 countsByYear W25831330062021 @default.
• W2583133006 countsByYear W25831330062022 @default.
• W2583133006 countsByYear W25831330062023 @default.
• W2583133006 crossrefType "journal-article" @default.
• W2583133006 hasAuthorship W2583133006A5008711004 @default.
• W2583133006 hasAuthorship W2583133006A5016909042 @default.
• W2583133006 hasAuthorship W2583133006A5020590496 @default.
• W2583133006 hasAuthorship W2583133006A5021639650 @default.
• W2583133006 hasAuthorship W2583133006A5024534843 @default.
• W2583133006 hasAuthorship W2583133006A5026222209 @default.
• W2583133006 hasAuthorship W2583133006A5031451451 @default.
• W2583133006 hasAuthorship W2583133006A5034821104 @default.

• next