Matches in SemOpenAlex for { <https://semopenalex.org/work/W2583304786> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2583304786 abstract "Abstract Abstract 4655 Objective: Thromboembolic events are common symptoms in patients with cancer, and the mechanisms are not totally understood. The platelet adhesion moleculars play important roles in the process of thrombus formation. The aim of the current study is to investigate the surface expression of platelet glycoprotein (GP) Ibα, GPIIb/IIIa, and P-selectin in patients with lung cancer. Method: Platelets were isolated from patients with lung cancer and normal volunteers, and then the surface expressions of platelet GP Ibα, GPIIb/IIIa, and P-selectin were measured by Flow cytometry. The glycocalicin (GC) fragments in the peripheral blood of patients with lung cancer were tested by Western blot. The surface expression of GP Ibα on normal volunteers' platelets incubated with the platelet-poor plasma (PPP) of patients with lung cancer was measured by Flow cytometry and Western blot. Results: The surface expressions of platelet GP Ibα, GPIIb/IIIa, and P-selectin were obviously increased in patients with lung cancer compared with that of normal volunteers, and the GC fragments in PPP were also increased in patients with lung cancer. Incubation of control platelets with the PPP from cancer patients resulted in the elevation of the surface expression of GP Ibα in control platelets. Furthermore, the expressions of GP Ibα, GPIIb/IIIa, and P-selectin on platelets from patients with advanced stage of lung cancer (III-IV stage) were significantly higher than those with early stage (I-II stage) (P<0.05). However, there were not significantly difference in the surface expressions of GP Ibα, GPIIb/IIIa, and P-selectin among the pathological types of lung cancer (squamous cell carcinoma, adenocarcinoma, small cell lung carcinoma, large cell lung carcinoma) (P>0.05). Conclusion: The surface expressions of platelet GP Ibα, GPIIb/IIIa, and P-selectin were obviously elevated in patients with lung cancer, and the plasma from cancer patients is responsible for the elevations. These findings provide a new view to understand the pathogenic mechanisms of thromboembolic events in the patients with lung cancer. Disclosures: No relevant conflicts of interest to declare." @default.
- W2583304786 created "2017-02-10" @default.
- W2583304786 creator A5010417792 @default.
- W2583304786 creator A5038784500 @default.
- W2583304786 creator A5055975671 @default.
- W2583304786 creator A5059381717 @default.
- W2583304786 creator A5084083030 @default.
- W2583304786 date "2012-11-16" @default.
- W2583304786 modified "2023-09-28" @default.
- W2583304786 title "Surface Expressions of Platelet Glycoprotein Ibα, GpIIb/IIIa, and P-Selectin Are Elevated in Lung Cancer Patients" @default.
- W2583304786 doi "https://doi.org/10.1182/blood.v120.21.4655.4655" @default.
- W2583304786 hasPublicationYear "2012" @default.
- W2583304786 type Work @default.
- W2583304786 sameAs 2583304786 @default.
- W2583304786 citedByCount "0" @default.
- W2583304786 crossrefType "journal-article" @default.
- W2583304786 hasAuthorship W2583304786A5010417792 @default.
- W2583304786 hasAuthorship W2583304786A5038784500 @default.
- W2583304786 hasAuthorship W2583304786A5055975671 @default.
- W2583304786 hasAuthorship W2583304786A5059381717 @default.
- W2583304786 hasAuthorship W2583304786A5084083030 @default.
- W2583304786 hasConcept C104317684 @default.
- W2583304786 hasConcept C121608353 @default.
- W2583304786 hasConcept C126322002 @default.
- W2583304786 hasConcept C185592680 @default.
- W2583304786 hasConcept C203014093 @default.
- W2583304786 hasConcept C26828662 @default.
- W2583304786 hasConcept C2776256026 @default.
- W2583304786 hasConcept C2776415932 @default.
- W2583304786 hasConcept C2781362458 @default.
- W2583304786 hasConcept C2910542480 @default.
- W2583304786 hasConcept C3018697912 @default.
- W2583304786 hasConcept C553184892 @default.
- W2583304786 hasConcept C55493867 @default.
- W2583304786 hasConcept C56701166 @default.
- W2583304786 hasConcept C71924100 @default.
- W2583304786 hasConcept C89560881 @default.
- W2583304786 hasConcept C90924648 @default.
- W2583304786 hasConceptScore W2583304786C104317684 @default.
- W2583304786 hasConceptScore W2583304786C121608353 @default.
- W2583304786 hasConceptScore W2583304786C126322002 @default.
- W2583304786 hasConceptScore W2583304786C185592680 @default.
- W2583304786 hasConceptScore W2583304786C203014093 @default.
- W2583304786 hasConceptScore W2583304786C26828662 @default.
- W2583304786 hasConceptScore W2583304786C2776256026 @default.
- W2583304786 hasConceptScore W2583304786C2776415932 @default.
- W2583304786 hasConceptScore W2583304786C2781362458 @default.
- W2583304786 hasConceptScore W2583304786C2910542480 @default.
- W2583304786 hasConceptScore W2583304786C3018697912 @default.
- W2583304786 hasConceptScore W2583304786C553184892 @default.
- W2583304786 hasConceptScore W2583304786C55493867 @default.
- W2583304786 hasConceptScore W2583304786C56701166 @default.
- W2583304786 hasConceptScore W2583304786C71924100 @default.
- W2583304786 hasConceptScore W2583304786C89560881 @default.
- W2583304786 hasConceptScore W2583304786C90924648 @default.
- W2583304786 hasLocation W25833047861 @default.
- W2583304786 hasOpenAccess W2583304786 @default.
- W2583304786 hasPrimaryLocation W25833047861 @default.
- W2583304786 hasRelatedWork W1990705137 @default.
- W2583304786 hasRelatedWork W2013589171 @default.
- W2583304786 hasRelatedWork W2017127297 @default.
- W2583304786 hasRelatedWork W20205116 @default.
- W2583304786 hasRelatedWork W2033626947 @default.
- W2583304786 hasRelatedWork W2088117527 @default.
- W2583304786 hasRelatedWork W2126637741 @default.
- W2583304786 hasRelatedWork W2156051763 @default.
- W2583304786 hasRelatedWork W2347552960 @default.
- W2583304786 hasRelatedWork W2368970751 @default.
- W2583304786 hasRelatedWork W2397817358 @default.
- W2583304786 hasRelatedWork W2407594696 @default.
- W2583304786 hasRelatedWork W2410810500 @default.
- W2583304786 hasRelatedWork W2412485763 @default.
- W2583304786 hasRelatedWork W2418276776 @default.
- W2583304786 hasRelatedWork W2419039385 @default.
- W2583304786 hasRelatedWork W2461466484 @default.
- W2583304786 hasRelatedWork W2588347178 @default.
- W2583304786 hasRelatedWork W2603943301 @default.
- W2583304786 hasRelatedWork W2750853665 @default.
- W2583304786 isParatext "false" @default.
- W2583304786 isRetracted "false" @default.
- W2583304786 magId "2583304786" @default.
- W2583304786 workType "article" @default.