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- W2583348261 abstract "An astonishing variety of membrane structures can be observed in the cellular environment, both at the plasma membrane and at the organelles. These shapes are intricately related to biological function, enabling and regulating fundamental cellular processes such as vesicle trafficking, signaling, or vectorial synthesis in the endoplasmic reticulum. Yet, most of the membrane structures observed experimentally are unstable from the stand point of lipid membrane thermodynamics, unable to retain their shape without the contribution of curvature inducing proteins. Here, we aim to answer the following fundamental question: given a cellular membrane structure, what is the distribution and concentration of curvature inducing proteins necessary to maintain this shape? Based on Helfrich model extended for protein surface diffusion, we solve the shape equation on fixed geometries of biological relevance, in order to find the field of spontaneous curvature that stabilize the membrane structure. We further relate the spontaneous curvature to protein density, bending ability, and membrane tension. We first investigate the role of spontaneous curvature in minimal surfaces, which includes catenoids — relevant to vesicle trafficking, tubulation, and nuclear pores — and helicoids — relevant to endoplasmic reticulum ramps. In these cases, the shape equation reduces to an heterogenous Helmholtz equation for the spontaneous curvature, where the source term is proportional to the Gaussian curvature. We show that this latter quantity alone is responsible for non-uniform distribution of spontaneous curvature in minimal surfaces. We then expand our analysis to more general surfaces, and identify instabilities in spontaneous curvature intensity, pointing out the need for distinct proteins at different stages of membrane shaping processes. We demonstrate how heterogeneities in spontaneous curvature distribution maintain energetically expensive membrane shapes at lower cost." @default.
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- W2583348261 date "2017-02-01" @default.
- W2583348261 modified "2023-09-25" @default.
- W2583348261 title "Stabilization of Cell Membrane Structures by Curvature-Inducing Proteins" @default.
- W2583348261 doi "https://doi.org/10.1016/j.bpj.2016.11.2090" @default.
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