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- W2583384907 abstract "Golgi-associated microtubules (GMTs) are a group of microtubules (MTs) derived from the Golgi membrane. Previous studies have demonstrated that the asymmetric GMTs are required for the proper organization of Golgi complex and the establishment of cell polarity. However, the underlying mechanisms that differ GMTs from other MTs remain unexplored. Here, combining single molecule tracking and super-resolution imaging, we found that GMTs support efficient vesicles transport of Golgi cargos. Vesicles on GMTs exhibit much more active transportation than that on non-Golgi-derived MTs. Moreover, GMTs are usually hyper-acetylated. Our study suggests that the acetylation modification turns GMTs into high ways facilitating Golgi cargo transport for establishment and maintenance of cell polarity." @default.
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- W2583384907 date "2017-02-01" @default.
- W2583384907 modified "2023-09-30" @default.
- W2583384907 title "Golgi Microtubules are Hyper-Acetylated and Participate in Fast Cargo Trafficking" @default.
- W2583384907 doi "https://doi.org/10.1016/j.bpj.2016.11.1303" @default.
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