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• W2583389968 abstract "Cell Labeling via Photobleaching (CLaP) is an optical technique recently developed to cross-link fluorescent molecules to the surface of individual cells, by focusing a low-power laser on their membrane. Using CLaP, it is possible select single cells or a sub-population based on visual criteria without the need of molecular markers. This technology can also be exploited for inducing transient cell adhesion to culture substrates, which are resistant to dissociation agents such as EDTA or trypsin. Since only the illuminated cells remain attached to the dish surface, CLaP can be exploited to tailor the spatial distribution of cells in a culture dish, and also to enrich the proportion of a chosen phenotype within proliferating cells.Breast cancer cell line MDA-MB-231 is known for its potential to metastasize to secondary sites. Among the various factors influencing their metastatic ability, epithelial to mesenchymal transformation and its reverse, mesenchymal to epithelial transformation, are required for cells to leave the tumor primary site, migrate and establish metastases at secondary sites. Here we assess the heterogeneity in motility and morphology of these cancer cells via time-lapse microscopy, automated segmentation and tracking. We use CLaP as a way to select clones of proliferating cells based on morphological and behavioral characteristics, to enrich cell cultures of specific phenotypes. We validate which of these traits are preserved after cell division, and which ones are affected by exposure to different conditioned media promoting mesenchymal to epithelial transformation." @default.
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• W2583389968 date "2017-02-01" @default.
• W2583389968 modified "2023-09-28" @default.
• W2583389968 title "Cell Line Phenotypic Enrichement based on Migration and Morphology" @default.
• W2583389968 doi "https://doi.org/10.1016/j.bpj.2016.11.744" @default.
• W2583389968 hasPublicationYear "2017" @default.
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