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- W2583478681 abstract "A heme-binding assay based on mass spectrometry was performed on P. monodiana Maire (Asteraceae) extracts to identify metabolites able to form adducts with heminic part of haemoglobin, as potential antimalarial drugs. Main adducts were characterized and their stability was measured. Isolation of main constituents of P. monodiana Maire lead to identification of the two methoxyflavones 3′-O-methyleupatorin (7) and artemetin (8) involved in the adducts formation. Four seco-tanapartholides (1–4), a guaianolide (5), a germacranolide (6) and two other methoxyflavones (9, 10) were also characterized. Evaluation of isolated compounds on P. falciparum and T. brucei brucei showed a moderate antiprotozoal activity of the two methoxyflavones." @default.
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- W2583478681 date "2017-04-01" @default.
- W2583478681 modified "2023-10-12" @default.
- W2583478681 title "Heme-binding activity of methoxyflavones from Pentzia monodiana Maire (Asteraceae)" @default.
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- W2583478681 doi "https://doi.org/10.1016/j.fitote.2017.01.012" @default.
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