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- W2583497312 abstract "The aim of this study is to assess safety/efficacy of yttrium-90 radioembolization (Y90) in patients with recurrent hepatocellular carcinoma (HCC) who have previously undergone surgical resection. With IRB approval, we searched our prospectively acquired database for consecutive patients with recurrent HCC following surgical resection that subsequently underwent Y90. Baseline characteristics and bilirubin toxicities (CTCAE v 4.0) following Y90 were evaluated. Intention to treat survival following date of first Y90 was calculated using Kaplan-Meier analysis. 39 patients met study inclusion criteria; median time from HCC surgical resection to first radioembolization was 19 months (95% CI: 13-37). The mean number of Y90 treatment sessions was 1.8 (range: 1-5). 9 patients received lobar treatment while 30 patients received selective (≤2 hepatic segments) treatment. Grade 1/2/3/4 bilirubin toxicity was seen in 7(17.9%)/4(10.2%)/5(12.8%)/1(2.5%) patients following Y90. No statistically significant differences in grade 1/2/3/4 bilirubin toxicities was identified when lobar [4(44%)/3(33%)/1(11%)/0] or selective [3(10%)/1(3%)/4(13%)/1(3%)] approach was utilized (P = 0.27). Two patients (5%) had biliary-enteric anastomoses during surgical resection. No post-Y90 infectious complications were identified. The median survival of the cohort is 30.3 months (CI: 12.2-46.7). Four patients went on to undergo liver transplantation. Radioembolization is a safe and effective method to treat recurrent HCC following surgical resection. No statistically significant difference in bilirubin toxicity was identified between patients who received lobar or selective treatments." @default.
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- W2583497312 date "2017-02-01" @default.
- W2583497312 modified "2023-09-26" @default.
- W2583497312 title "Radioembolization for recurrent hepatocellular carcinoma after surgical resection: safety and long-term outcomes" @default.
- W2583497312 doi "https://doi.org/10.1016/j.jvir.2016.12.890" @default.
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