FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2583643003> ?p ?o ?g. }

• W2583643003 endingPage "582" @default.
• W2583643003 startingPage "576" @default.
• W2583643003 abstract "The homeostasis of muscle properties depends on both physical and metabolic stresses. Whereas physical stress entails metabolic response for muscle homeostasis, the latter does not necessarily involve the former and may thus solely affect the homeostasis. We here report that metabolic suppression by the hypometabolic agent 3-iodothyronamine (T1AM) induced muscle cell atrophy without physical stress. We observed that the oxygen consumption rate of C2C12 myotubes decreased 40% upon treatment with 75 µM T1AM for 6 h versus 10% in the vehicle (dimethyl sulfoxide) control. The T1AM treatment reduced cell diameter of myotubes by 15% compared to the control (p<0.05). The cell diameter was reversed completely by 9 h after T1AM was removed. The T1AM treatment also significantly suppressed the expression levels of heat shock protein 72 and αB-crystallin as well as the phosphorylation levels of Akt1, mammalian target of rapamycin (mTOR), S6K, forkhead box O1 (FoxO1) and FoxO3. In contrast, the levels of ubiquitin E3 ligase MuRF1 and chymotrypsin-like activity of proteasome were significantly elevated by T1AM treatment. These results suggest that T1AM-mediated metabolic suppression induced muscle cell atrophy via activation of catabolic signaling and inhibition of anabolic signaling." @default.
• W2583643003 created "2017-02-10" @default.
• W2583643003 creator A5007966510 @default.
• W2583643003 creator A5020382624 @default.
• W2583643003 creator A5058192555 @default.
• W2583643003 creator A5071464303 @default.
• W2583643003 creator A5072448709 @default.
• W2583643003 creator A5078717180 @default.
• W2583643003 creator A5085445013 @default.
• W2583643003 date "2017-01-01" @default.
• W2583643003 modified "2023-10-06" @default.
• W2583643003 title "Metabolic Suppression by 3-Iodothyronamine Induced Muscle Cell Atrophy <i>via</i> Activation of FoxO–Proteasome Signaling and Downregulation of Akt1–S6K Signaling" @default.
• W2583643003 cites W1483221926 @default.
• W2583643003 cites W1926115347 @default.
• W2583643003 cites W1966824338 @default.
• W2583643003 cites W1980638751 @default.
• W2583643003 cites W1988464904 @default.
• W2583643003 cites W1994439048 @default.
• W2583643003 cites W1997559000 @default.
• W2583643003 cites W1999610793 @default.
• W2583643003 cites W2002563734 @default.
• W2583643003 cites W2009525986 @default.
• W2583643003 cites W2015454275 @default.
• W2583643003 cites W2033797333 @default.
• W2583643003 cites W2044874695 @default.
• W2583643003 cites W2048046939 @default.
• W2583643003 cites W2060243818 @default.
• W2583643003 cites W2072809212 @default.
• W2583643003 cites W2092826514 @default.
• W2583643003 cites W2093361751 @default.
• W2583643003 cites W2101991847 @default.
• W2583643003 cites W2107908178 @default.
• W2583643003 cites W2114796514 @default.
• W2583643003 cites W2136047357 @default.
• W2583643003 cites W2139987952 @default.
• W2583643003 cites W2143079214 @default.
• W2583643003 cites W2144175766 @default.
• W2583643003 cites W2144293442 @default.
• W2583643003 cites W2154584639 @default.
• W2583643003 cites W2166978593 @default.
• W2583643003 cites W2168551727 @default.
• W2583643003 cites W2170722828 @default.
• W2583643003 cites W2176504547 @default.
• W2583643003 cites W2325828778 @default.
• W2583643003 doi "https://doi.org/10.1248/bpb.b16-00653" @default.
• W2583643003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28163294" @default.
• W2583643003 hasPublicationYear "2017" @default.
• W2583643003 type Work @default.
• W2583643003 sameAs 2583643003 @default.
• W2583643003 citedByCount "4" @default.
• W2583643003 countsByYear W25836430032018 @default.
• W2583643003 countsByYear W25836430032021 @default.
• W2583643003 crossrefType "journal-article" @default.
• W2583643003 hasAuthorship W2583643003A5007966510 @default.
• W2583643003 hasAuthorship W2583643003A5020382624 @default.
• W2583643003 hasAuthorship W2583643003A5058192555 @default.
• W2583643003 hasAuthorship W2583643003A5071464303 @default.
• W2583643003 hasAuthorship W2583643003A5072448709 @default.
• W2583643003 hasAuthorship W2583643003A5078717180 @default.
• W2583643003 hasAuthorship W2583643003A5085445013 @default.
• W2583643003 hasBestOaLocation W25836430031 @default.
• W2583643003 hasConcept C104202773 @default.
• W2583643003 hasConcept C104317684 @default.
• W2583643003 hasConcept C126322002 @default.
• W2583643003 hasConcept C134018914 @default.
• W2583643003 hasConcept C134459356 @default.
• W2583643003 hasConcept C140149449 @default.
• W2583643003 hasConcept C185592680 @default.
• W2583643003 hasConcept C25602115 @default.
• W2583643003 hasConcept C2776263037 @default.
• W2583643003 hasConcept C2779959927 @default.
• W2583643003 hasConcept C3763915 @default.
• W2583643003 hasConcept C55493867 @default.
• W2583643003 hasConcept C62478195 @default.
• W2583643003 hasConcept C63645605 @default.
• W2583643003 hasConcept C71924100 @default.
• W2583643003 hasConcept C75217442 @default.
• W2583643003 hasConcept C86554907 @default.
• W2583643003 hasConcept C86803240 @default.
• W2583643003 hasConcept C95444343 @default.
• W2583643003 hasConceptScore W2583643003C104202773 @default.
• W2583643003 hasConceptScore W2583643003C104317684 @default.
• W2583643003 hasConceptScore W2583643003C126322002 @default.
• W2583643003 hasConceptScore W2583643003C134018914 @default.
• W2583643003 hasConceptScore W2583643003C134459356 @default.
• W2583643003 hasConceptScore W2583643003C140149449 @default.
• W2583643003 hasConceptScore W2583643003C185592680 @default.
• W2583643003 hasConceptScore W2583643003C25602115 @default.
• W2583643003 hasConceptScore W2583643003C2776263037 @default.
• W2583643003 hasConceptScore W2583643003C2779959927 @default.
• W2583643003 hasConceptScore W2583643003C3763915 @default.
• W2583643003 hasConceptScore W2583643003C55493867 @default.
• W2583643003 hasConceptScore W2583643003C62478195 @default.
• W2583643003 hasConceptScore W2583643003C63645605 @default.
• W2583643003 hasConceptScore W2583643003C71924100 @default.
• W2583643003 hasConceptScore W2583643003C75217442 @default.
• W2583643003 hasConceptScore W2583643003C86554907 @default.
• W2583643003 hasConceptScore W2583643003C86803240 @default.

• next