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- W2583669083 abstract "Although several therapeutic agents are available for psoriatic arthritis (PsA), each has limitations. Acthar® Gel (repository corticotropin injection) is FDA-approved for treatment of acute episodes or exacerbation of PsA, but no clinical trials have investigated it for those uses. This 28-week, prospective, single-center, open-label trial included subjects with moderately to severely active PsA. The primary outcome measure was ACR20 at Week 12. Secondary outcomes included ACR20 at Week 24, ACR50, ACR70, Clinical Disease Activity Index (CDAI), Psoriasis Area and Severity Index (PASI) 50, PASI 75, Physician Global Assessment, Patient Global Assessment, Tender and Swollen Joint Count, Visual Analog Scale (VAS) for measurement of pain, acute erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and pre-injection and post-injection cortisol levels at Weeks 12 and 24. Safety, including adverse events and vital signs, were monitored throughout. Among subjects initially enrolled (n = 15), 8 completed Week 12; 7 finished Week 24." @default.
- W2583669083 created "2017-02-10" @default.
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- W2583669083 date "2016-10-31" @default.
- W2583669083 modified "2023-09-25" @default.
- W2583669083 title "A Single-Site, Investigator Initiated Open-Label Trial of H.P. Acthar® Gel (Repository Corticotropin Injection) an Adrenocorticotropic Hormone (ACTH) Analogue in Subjects with Moderately to Severely Active Psoriatic Arthritis (PsA)" @default.
- W2583669083 doi "https://doi.org/10.23937/2469-5750/1510037" @default.
- W2583669083 hasPublicationYear "2016" @default.
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