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• W2583704003 abstract "Materials and methods . After Local Ethics Committee approval and obtaining informed consent, 103 patients were prospectively divided into 4 groups depending on the characteristics of post-operative intensive care. Patients were conducted surgery on the abdomen by laparotomy about peritonitis. In the 1 (control) group (n=27), patients after operation received stimulation of the gastrointestinal tract with metoclopramidum and neostigminum. In group 2 (n=24), patients received L-arginine and metoclopramidum. In the group 3 (n=25) patients received metoclopramidum and simeticonum. In group 4 (n=27), patients received L-arginine, metoclopramidum and simeticonum. The value of IAP studied preoperatively, after 1,2 and 3 days postoperatively. IAP was measured by indirect method in the bladder. Normal values of IAP we considered recommendations of World Abdominal compartment Society (WSACS). Also studied perfusion pressure in abdominal cavity (PP), ICU length of stay, length of stay in hospital, terms of restoring self-discharge of gases and timing recovery self-defecation. The end point of the study was 28 day after surgery. Statistical analysis of the data was performed using the software package Statistica v8.0. Results and Conclusion . Before surgery, we observed an increase in IAP in 63.1% of patients. The value of intra-abdominal pressure exceeded the upper limit of normal in 58.5% (p <0.001). After 1 day after surgery in all groups bowel dysmotility grew. Patients 1,3 and 4 groups IAP remained elevated, not statistically different from the preoperative. In 2 groups patients IAP was lower than in groups 3 and 4 by 28.6% (p <0.001) and 32.3% (p <0.001), respectively, 21.2% (p = 0.018) were lower than the preoperative. The maximum increase in IAP patients in all groups, we observed 2 days after surgery. The number of patients with increased IAP was different between groups. Thus, 1, 3 and 4 group 100% of patients had elevated IAP, whereas in group 2 – 20% of patients had normal its value. After 3 days after surgery IAP decreased in all groups. Most patients with elevated IAP was in groups 1 and 4 – 58.8% and 48.5%, respectively. In these groups, the mean value exceeded the norm by 27% (p = 0.037) and 39.6% (p <0.001) was on the preoperative level, but did not reach IAH 1. Patients 2 and 3 of the average value of IAP was lower relative to preoperative levels by 30.9% (p <0.001) and 30.1% (p = 0.04), respectively. PP was in the normal range and did not statistically differ between groups. The most rapid recovery after bowel surgery patients were 2 groups. The application of metoclopramide and L-arginine self discharge gas is observed after 2.22 days after surgery. This is 21.8% (p = 0.001) was lower than in group 1, 29.7% (p <0.001) – 3 group, 26.6% (p = 0.003) – 4 groups. Length of stay in ICU and stay in the hospital in group 2 decreased insignificantly. Mortality at 28 days is the same in all groups." @default.
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• W2583704003 date "2015-04-09" @default.
• W2583704003 modified "2023-09-25" @default.
• W2583704003 title "Intra-abdominal pressure during different methods of drug stimulation of gastrointestinal trast after operations on the abdominal cavity" @default.
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• W2583704003 doi "https://doi.org/10.25284/2519-2078.2(71).2015.84674" @default.
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