Matches in SemOpenAlex for { <https://semopenalex.org/work/W2583707935> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2583707935 abstract "Mutations in cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy affecting millions of people worldwide. Recent studies established that the N-terminal domains (NTDs) of cMyBP-C (e.g., C0, C1, M, and C2) can bind to and activate or inhibit the thin filament (TF). However, the molecular mechanism(s) by which NTDs modulate interaction of myosin with the TF remains unknown. Recently, we demonstrated that despite being structural homologs, C0 and C1 NTDs exhibit different patterns of binding on the surface of F-actin. Moreover, we showed that C1 but not C0 can activate the TF by means of shifting the tropomyosin (Tm) cable from the “closed” to the “open” structural state via direct interaction with Tm. Here we used cryo electron microscopy and image analysis to reveal how C0 and C1 Ig-domains connected by the Proline/Alanine-linker communicate with each other when interacting with the TF in tandem. Our results show that C0 binds to the front of actin subdomain-1 in two distinct modes, and that in these two modes C0 has different effect on the interaction of C1 domain with both actin filament and Tm cable. In one mode C0 enhances the activating effect of C1 domain so that the Tm cable is shifted towards the subdomain-4 of actin to an even larger extent than found in the “open” state of Tm. In the second mode C0 reverses the activation effect of C1 by means of disrupting the interaction of C1 with Tm. Importantly, we demonstrate that the two domains communicate with each other allosterically through the actin filament. Our data suggest that the internal dynamics of the actin molecule is essential for the regulation of the actomyosin interaction in cardiac muscle. We propose a mechanism by which cMyBP-C may modulate actomyosin interactions in cardiac muscle." @default.
- W2583707935 created "2017-02-10" @default.
- W2583707935 creator A5010993930 @default.
- W2583707935 creator A5013547827 @default.
- W2583707935 creator A5029073594 @default.
- W2583707935 creator A5061780801 @default.
- W2583707935 creator A5067579006 @default.
- W2583707935 creator A5068517610 @default.
- W2583707935 creator A5081307424 @default.
- W2583707935 creator A5086462753 @default.
- W2583707935 date "2017-02-01" @default.
- W2583707935 modified "2023-09-30" @default.
- W2583707935 title "C0 Domain of Cardiac Myosin Binding Protein-C Modulates Interaction of the Neighboring C1 Domain with Tropomyosin Through the Allosteric Interaction with F-Actin" @default.
- W2583707935 doi "https://doi.org/10.1016/j.bpj.2016.11.3023" @default.
- W2583707935 hasPublicationYear "2017" @default.
- W2583707935 type Work @default.
- W2583707935 sameAs 2583707935 @default.
- W2583707935 citedByCount "0" @default.
- W2583707935 crossrefType "journal-article" @default.
- W2583707935 hasAuthorship W2583707935A5010993930 @default.
- W2583707935 hasAuthorship W2583707935A5013547827 @default.
- W2583707935 hasAuthorship W2583707935A5029073594 @default.
- W2583707935 hasAuthorship W2583707935A5061780801 @default.
- W2583707935 hasAuthorship W2583707935A5067579006 @default.
- W2583707935 hasAuthorship W2583707935A5068517610 @default.
- W2583707935 hasAuthorship W2583707935A5081307424 @default.
- W2583707935 hasAuthorship W2583707935A5086462753 @default.
- W2583707935 hasBestOaLocation W25837079351 @default.
- W2583707935 hasConcept C107824862 @default.
- W2583707935 hasConcept C111919701 @default.
- W2583707935 hasConcept C11804247 @default.
- W2583707935 hasConcept C12554922 @default.
- W2583707935 hasConcept C125705527 @default.
- W2583707935 hasConcept C14228908 @default.
- W2583707935 hasConcept C166342909 @default.
- W2583707935 hasConcept C170493617 @default.
- W2583707935 hasConcept C185592680 @default.
- W2583707935 hasConcept C205875245 @default.
- W2583707935 hasConcept C25166345 @default.
- W2583707935 hasConcept C2780557392 @default.
- W2583707935 hasConcept C41008148 @default.
- W2583707935 hasConcept C51639874 @default.
- W2583707935 hasConcept C55493867 @default.
- W2583707935 hasConcept C6997183 @default.
- W2583707935 hasConcept C8010536 @default.
- W2583707935 hasConcept C86803240 @default.
- W2583707935 hasConcept C95444343 @default.
- W2583707935 hasConceptScore W2583707935C107824862 @default.
- W2583707935 hasConceptScore W2583707935C111919701 @default.
- W2583707935 hasConceptScore W2583707935C11804247 @default.
- W2583707935 hasConceptScore W2583707935C12554922 @default.
- W2583707935 hasConceptScore W2583707935C125705527 @default.
- W2583707935 hasConceptScore W2583707935C14228908 @default.
- W2583707935 hasConceptScore W2583707935C166342909 @default.
- W2583707935 hasConceptScore W2583707935C170493617 @default.
- W2583707935 hasConceptScore W2583707935C185592680 @default.
- W2583707935 hasConceptScore W2583707935C205875245 @default.
- W2583707935 hasConceptScore W2583707935C25166345 @default.
- W2583707935 hasConceptScore W2583707935C2780557392 @default.
- W2583707935 hasConceptScore W2583707935C41008148 @default.
- W2583707935 hasConceptScore W2583707935C51639874 @default.
- W2583707935 hasConceptScore W2583707935C55493867 @default.
- W2583707935 hasConceptScore W2583707935C6997183 @default.
- W2583707935 hasConceptScore W2583707935C8010536 @default.
- W2583707935 hasConceptScore W2583707935C86803240 @default.
- W2583707935 hasConceptScore W2583707935C95444343 @default.
- W2583707935 hasLocation W25837079351 @default.
- W2583707935 hasOpenAccess W2583707935 @default.
- W2583707935 hasPrimaryLocation W25837079351 @default.
- W2583707935 hasRelatedWork W1964681919 @default.
- W2583707935 hasRelatedWork W2000843281 @default.
- W2583707935 hasRelatedWork W2013953837 @default.
- W2583707935 hasRelatedWork W2032980303 @default.
- W2583707935 hasRelatedWork W2052395012 @default.
- W2583707935 hasRelatedWork W2059374700 @default.
- W2583707935 hasRelatedWork W2060099568 @default.
- W2583707935 hasRelatedWork W2068182553 @default.
- W2583707935 hasRelatedWork W2071259484 @default.
- W2583707935 hasRelatedWork W2100205501 @default.
- W2583707935 hasRelatedWork W2136635838 @default.
- W2583707935 hasRelatedWork W2401608313 @default.
- W2583707935 hasRelatedWork W2481748615 @default.
- W2583707935 hasRelatedWork W2584051994 @default.
- W2583707935 hasRelatedWork W2948644088 @default.
- W2583707935 hasRelatedWork W2978801098 @default.
- W2583707935 hasRelatedWork W2992700989 @default.
- W2583707935 hasRelatedWork W3044044352 @default.
- W2583707935 hasRelatedWork W3093941869 @default.
- W2583707935 hasRelatedWork W3205147443 @default.
- W2583707935 isParatext "false" @default.
- W2583707935 isRetracted "false" @default.
- W2583707935 magId "2583707935" @default.
- W2583707935 workType "article" @default.