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• W2583934085 abstract "Obesity is a disease state of epidemic proportions in the United States and other industrialized countries, which can cause and/or exacerbate diabetes (DM), obstructive sleep apnea (OSA), cardiovascular disease, cancers, and liver and renal disease [ 1 Kopelman P. Health risks associated with overweight and obesity. Obesity. 2007; 8: 12-17 Google Scholar , 2 NIDDK NIoDaDaKD Obesity and obesity statistics. 2013 Google Scholar ]. OSA is a relatively common problem with about 20% of adults presenting with at least mild OSA and about one in 15 presenting with moderate or severe OSA [ [3] Young T. Peppard P. Gottlieb D. The epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002; 165: 1217-1239 Crossref PubMed Scopus (3308) Google Scholar ]. OSA often occurs as a comorbidity of obesity and DM, but it also contributes to worsening of DM, at least in part independently from obesity, and leads to increased morbidity and mortality from DM, cardiovascular disease, and accidents caused by excessive daytime sleepiness [ 4 Aron-Wisnewsky J. Clement K. Pepin J.L. Nonalcoholic fatty liver disease and obstructive sleep apnea. Metabolism. 2016; 65: 1124-1135 Abstract Full Text Full Text PDF PubMed Scopus (69) Google Scholar , 5 Hayley A.C. Williams L.J. Kennedy G.A. Berk M. Brennan S.L. Pasco J.A. Excessive daytime sleepiness and metabolic syndrome: a cross-sectional study. Metabolism. 2015; 64: 244-252 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar , 6 Aziz F. Chaudhary K. The triad of sleep apnea, hypertension, and chronic kidney disease: a spectrum of common pathology. Cardiorenal Med. 2016; 7: 74-82 Crossref PubMed Scopus (14) Google Scholar , 7 Campos-Rodriguez F. Martinez-Garcia M.A. Reyes-Nunez N. Selma-Ferrer M.J. Punjabi N.M. Farre R. Impact of different hypopnea definitions on obstructive sleep apnea severity and cardiovascular mortality risk in women and elderly individuals. Sleep Med. 2016; 27–28: 54-58 Abstract Full Text Full Text PDF PubMed Scopus (23) Google Scholar ]. Indeed, the risk of OSA increases with both age and BMI with a prevalence of up to 80% in the highest risk categories [ [8] Peppard P.E. Young T. Barnet J.H. Palta M. Hagen E.W. Hla K.M. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013; 177: 1006-1014 Crossref PubMed Scopus (2700) Google Scholar ] for this unmet clinical need." @default.
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• W2583934085 date "2017-04-01" @default.
• W2583934085 modified "2023-09-27" @default.
• W2583934085 title "Sleep apnea in relation to metabolism: An urgent need to study underlying mechanisms and to develop novel treatments for this unmet clinical need" @default.
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• W2583934085 doi "https://doi.org/10.1016/j.metabol.2017.01.028" @default.
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