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- W2584067539 abstract "To report long-term outcomes of yttrium-90 radioembolization for hepatocellular carcinoma (HCC). Patients with HCC (N = 948) were treated with radioembolization as part of a single-center, prospective, longitudinal cohort study (2003-2016). Retrospective chart and imaging review was performed and patients were staged using BCLC criteria (without ECOG). Overall survival (OS) was estimated after censoring to surgical resection or orthotopic liver transplantation (OLT) using Kaplan Meier survival analysis. Multivariate analysis was performed using the Cox regression model and hazards ratios (HR) were calculated. 375 (39%), 208 (22%), 327 (34%), and 38 (5%) patients were BCLC A, B, C, and D, respectively. 151 (16%) received OLT with a median time to OLT of 6.6 months (range: 0.3–34). 30 (3%) patients underwent hepatic resection within median time to resection of 2.9 months (95% CI: 0.9-25.5). Median OS (months) (95% CI) for BCLC A/B/C/D were [34.4(29-47.3)/15.7(13.8-21.4)/8(7.3-9)/6(4.4-16)]. Median OS (95% CI) for patients within Milan criteria was 37.2 months (29.1- 70.2). Median OS (95%CI) for Child-Pugh A (N = 188) within Milan criteria (N = 188) is 67.5 months (37.2-80.2) (5-year survival probability of 54%). 272 (29%) patients had portal vein thrombosis with a median OS of 7 months (95% CI: 5.8-7.8) while 84 (9%) patients had metastases with a median OS of 7.2 months (95% CI: 5.4-8.6). On multivariate analysis, baseline AFP >200 ng/mL (HR: 1.6; 95% CI: 1.4-2), ALBI grade (HR 1.7; 95% CI: 1.5-2.0), BCLC (HR 1.4; 95% CI: 1.2-1.6), PVT (HR: 1.8; 95% CI: 1.4-2.2) and metastases (HR: 1.9; 95% CI: 1.4-2.5) were statistically significant prognosticators of survival (P<0.0001). Radioembolization results in survival outcomes that are affected by the baseline characteristics. Patients with preserved liver function (CP A) within Milan criteria demonstrate improved long-term outcomes with a median survival of 67.5 months. This type of analysis using big data permits substratification of patients and identification of those that may benefit maximally from radioembolization." @default.
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- W2584067539 date "2017-02-01" @default.
- W2584067539 modified "2023-09-26" @default.
- W2584067539 title "Survival outcomes following radioembolization for hepatocellular carcinoma: results from a 948-patient cohort" @default.
- W2584067539 doi "https://doi.org/10.1016/j.jvir.2016.12.775" @default.
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