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- W2584082028 endingPage "280" @default.
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- W2584082028 abstract "Cancer cells are heavily dependent on maintaining protein homeostasis in order to support their uncontrolled growth and proliferation. Consequently, cancer cells are vulnerable to inhibition of the various processes involved in protein homeostasis including protein synthesis, protein folding, and protein degradation. In this article, we review the discovery of inhibitors of protein synthesis, including inhibitors of both transcription and translation, as anticancer therapeutics. Inhibitors of molecular chaperones are reviewed and the progression of these toward the clinic for the treatment of a range of cancers is presented. Finally, we review the progress in the discovery and development of inhibitors of protein degradation, including approved proteasome inhibitors along with inhibitors of other targets in this area." @default.
- W2584082028 created "2017-02-10" @default.
- W2584082028 creator A5012837749 @default.
- W2584082028 creator A5054721885 @default.
- W2584082028 creator A5056212024 @default.
- W2584082028 creator A5078401740 @default.
- W2584082028 date "2017-01-01" @default.
- W2584082028 modified "2023-10-14" @default.
- W2584082028 title "Targeting Protein Synthesis, Folding, and Degradation Pathways in Cancer" @default.
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