FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2584206871> ?p ?o ?g. }

• W2584206871 endingPage "853" @default.
• W2584206871 startingPage "848" @default.
• W2584206871 abstract "Multidrug resistance (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene is major obstacles for successful cancer chemotherapy. P-gp could extrude anti-cancer drugs out of cancer cells and decrease effective intracellular drug concentrations. MDR reversal agents for P-gp can restore the sensitivity of MDR cells to such drugs. Saikosaponin D (SSd), one of the major triterpenoid saponins derived from Bupleurum chinense DC (BCDC), has been shown to possess anti-inflammatory, anti-infectious and anti-tumor properties. The aim of the present study was to investigate the reversal effect of SSd on MDR in MCF-7/adriamycin (ADR) human breast cancer cells and investigate the underlying mechanisms of SSd. The results demonstrated that SSd inhibited the proliferation of MCF-7/ADR and MCF-7 cells in a dose-dependent manner. Moreover, SSd increased the cytotoxicity of ADR on MCF-7/ADR cells and the resistance fold of SSd treatment was demonstrated to be significantly higher when compared with that of the group without SSd treatment. Additionally, the effects of the drug combination showed that SSd and ADR combination were synergistic. Accumulation and efflux studies with the P-gp substrate, rhodamine 123 (Rh123), demonstrated that SSd restored Rh123 accumulation and inhibited P-gp-mediated drug efflux. Importantly, we found that SSd could enhance the sensitivity of MCF-7/ADR cells towards ADR by down-regulating MDR1 and P-gp expression. In conclusion, the results of the present study indicated that SSd may represent a potent reversal agent for P-gp-mediated MDR in breast cancer therapy." @default.
• W2584206871 created "2017-02-10" @default.
• W2584206871 creator A5021954849 @default.
• W2584206871 creator A5034711601 @default.
• W2584206871 creator A5035327180 @default.
• W2584206871 creator A5037815059 @default.
• W2584206871 creator A5049078993 @default.
• W2584206871 creator A5073388349 @default.
• W2584206871 date "2017-07-01" @default.
• W2584206871 modified "2023-10-18" @default.
• W2584206871 title "Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells" @default.
• W2584206871 cites W1539481967 @default.
• W2584206871 cites W157723456 @default.
• W2584206871 cites W1580176919 @default.
• W2584206871 cites W1644828565 @default.
• W2584206871 cites W1980296966 @default.
• W2584206871 cites W1983173409 @default.
• W2584206871 cites W2006434892 @default.
• W2584206871 cites W2016409260 @default.
• W2584206871 cites W2038922541 @default.
• W2584206871 cites W2044154925 @default.
• W2584206871 cites W2049030825 @default.
• W2584206871 cites W2061270171 @default.
• W2584206871 cites W2073333066 @default.
• W2584206871 cites W2076833636 @default.
• W2584206871 cites W2077945404 @default.
• W2584206871 cites W2079150103 @default.
• W2584206871 cites W2096439168 @default.
• W2584206871 cites W2106787323 @default.
• W2584206871 cites W2119010359 @default.
• W2584206871 cites W2138935969 @default.
• W2584206871 cites W2169245481 @default.
• W2584206871 cites W2402288217 @default.
• W2584206871 cites W2414829702 @default.
• W2584206871 cites W42293926 @default.
• W2584206871 doi "https://doi.org/10.1016/j.prp.2017.01.022" @default.
• W2584206871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28554760" @default.
• W2584206871 hasPublicationYear "2017" @default.
• W2584206871 type Work @default.
• W2584206871 sameAs 2584206871 @default.
• W2584206871 citedByCount "28" @default.
• W2584206871 countsByYear W25842068712018 @default.
• W2584206871 countsByYear W25842068712019 @default.
• W2584206871 countsByYear W25842068712020 @default.
• W2584206871 countsByYear W25842068712021 @default.
• W2584206871 countsByYear W25842068712022 @default.
• W2584206871 countsByYear W25842068712023 @default.
• W2584206871 crossrefType "journal-article" @default.
• W2584206871 hasAuthorship W2584206871A5021954849 @default.
• W2584206871 hasAuthorship W2584206871A5034711601 @default.
• W2584206871 hasAuthorship W2584206871A5035327180 @default.
• W2584206871 hasAuthorship W2584206871A5037815059 @default.
• W2584206871 hasAuthorship W2584206871A5049078993 @default.
• W2584206871 hasAuthorship W2584206871A5073388349 @default.
• W2584206871 hasConcept C109316439 @default.
• W2584206871 hasConcept C109541995 @default.
• W2584206871 hasConcept C114851261 @default.
• W2584206871 hasConcept C121608353 @default.
• W2584206871 hasConcept C126322002 @default.
• W2584206871 hasConcept C133936738 @default.
• W2584206871 hasConcept C185592680 @default.
• W2584206871 hasConcept C200082930 @default.
• W2584206871 hasConcept C202751555 @default.
• W2584206871 hasConcept C2776694085 @default.
• W2584206871 hasConcept C2778589691 @default.
• W2584206871 hasConcept C2778707650 @default.
• W2584206871 hasConcept C2781303535 @default.
• W2584206871 hasConcept C2994423619 @default.
• W2584206871 hasConcept C502942594 @default.
• W2584206871 hasConcept C55493867 @default.
• W2584206871 hasConcept C71924100 @default.
• W2584206871 hasConcept C79879829 @default.
• W2584206871 hasConcept C86803240 @default.
• W2584206871 hasConcept C89423630 @default.
• W2584206871 hasConcept C96232424 @default.
• W2584206871 hasConcept C98274493 @default.
• W2584206871 hasConceptScore W2584206871C109316439 @default.
• W2584206871 hasConceptScore W2584206871C109541995 @default.
• W2584206871 hasConceptScore W2584206871C114851261 @default.
• W2584206871 hasConceptScore W2584206871C121608353 @default.
• W2584206871 hasConceptScore W2584206871C126322002 @default.
• W2584206871 hasConceptScore W2584206871C133936738 @default.
• W2584206871 hasConceptScore W2584206871C185592680 @default.
• W2584206871 hasConceptScore W2584206871C200082930 @default.
• W2584206871 hasConceptScore W2584206871C202751555 @default.
• W2584206871 hasConceptScore W2584206871C2776694085 @default.
• W2584206871 hasConceptScore W2584206871C2778589691 @default.
• W2584206871 hasConceptScore W2584206871C2778707650 @default.
• W2584206871 hasConceptScore W2584206871C2781303535 @default.
• W2584206871 hasConceptScore W2584206871C2994423619 @default.
• W2584206871 hasConceptScore W2584206871C502942594 @default.
• W2584206871 hasConceptScore W2584206871C55493867 @default.
• W2584206871 hasConceptScore W2584206871C71924100 @default.
• W2584206871 hasConceptScore W2584206871C79879829 @default.
• W2584206871 hasConceptScore W2584206871C86803240 @default.
• W2584206871 hasConceptScore W2584206871C89423630 @default.
• W2584206871 hasConceptScore W2584206871C96232424 @default.
• W2584206871 hasConceptScore W2584206871C98274493 @default.

• next