Matches in SemOpenAlex for { <https://semopenalex.org/work/W2584222766> ?p ?o ?g. }
- W2584222766 endingPage "314" @default.
- W2584222766 startingPage "295" @default.
- W2584222766 abstract "22q11.2 deletion syndrome is a neurogenetic disorder resulting in the deletion of over 40 genes. Up to 40% of individuals with 22q11.2DS develop schizophrenia, though little is known about the underlying mechanisms. We hypothesized that allelic variation in functional polymorphisms in seven genes unique to the deleted region would affect lobar brain volumes, which would predict risk for psychosis in youth with 22q11.2DS. Participants included 56 individuals (30 males) with 22q11.2DS. Anatomic MR images were collected and processed using Freesurfer. Participants were genotyped for 10 SNPs in the COMT, DGCR8, GNB1L, PIK4CA, PRODH, RTN4R, and ZDHHC8 genes. All subjects were assessed for ultra high risk symptoms of psychosis. Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428. Our results suggest that RTN4R, a relatively under-studied gene at the 22q11 locus, constitutes a susceptibility gene for psychosis in individuals with this syndrome through its alteration of the architecture of the brain. © 2017 Wiley Periodicals, Inc." @default.
- W2584222766 created "2017-02-10" @default.
- W2584222766 creator A5009355569 @default.
- W2584222766 creator A5025373205 @default.
- W2584222766 creator A5029636865 @default.
- W2584222766 creator A5044719215 @default.
- W2584222766 creator A5048707776 @default.
- W2584222766 creator A5052145058 @default.
- W2584222766 creator A5055540043 @default.
- W2584222766 creator A5073821308 @default.
- W2584222766 creator A5084347790 @default.
- W2584222766 creator A5084528838 @default.
- W2584222766 creator A5085778566 @default.
- W2584222766 date "2017-01-31" @default.
- W2584222766 modified "2023-09-26" @default.
- W2584222766 title "Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome" @default.
- W2584222766 cites W1489675466 @default.
- W2584222766 cites W1500809101 @default.
- W2584222766 cites W1506667049 @default.
- W2584222766 cites W1538860041 @default.
- W2584222766 cites W1586325690 @default.
- W2584222766 cites W1638444713 @default.
- W2584222766 cites W1922202581 @default.
- W2584222766 cites W1968392604 @default.
- W2584222766 cites W1970806500 @default.
- W2584222766 cites W1971129913 @default.
- W2584222766 cites W1971487909 @default.
- W2584222766 cites W1971624220 @default.
- W2584222766 cites W1972177455 @default.
- W2584222766 cites W1972402677 @default.
- W2584222766 cites W1980776446 @default.
- W2584222766 cites W1980991473 @default.
- W2584222766 cites W1982765225 @default.
- W2584222766 cites W1985996981 @default.
- W2584222766 cites W1986059489 @default.
- W2584222766 cites W1988023403 @default.
- W2584222766 cites W1989572846 @default.
- W2584222766 cites W1990041156 @default.
- W2584222766 cites W1990043440 @default.
- W2584222766 cites W1990044417 @default.
- W2584222766 cites W1993544641 @default.
- W2584222766 cites W2003539800 @default.
- W2584222766 cites W2006404298 @default.
- W2584222766 cites W2006473457 @default.
- W2584222766 cites W2006894540 @default.
- W2584222766 cites W2007991423 @default.
- W2584222766 cites W2009208718 @default.
- W2584222766 cites W2010576394 @default.
- W2584222766 cites W2012505689 @default.
- W2584222766 cites W2013514700 @default.
- W2584222766 cites W2020301473 @default.
- W2584222766 cites W2024062662 @default.
- W2584222766 cites W2025415714 @default.
- W2584222766 cites W2026287451 @default.
- W2584222766 cites W2029965540 @default.
- W2584222766 cites W2031608440 @default.
- W2584222766 cites W2032866243 @default.
- W2584222766 cites W2035268471 @default.
- W2584222766 cites W2038425641 @default.
- W2584222766 cites W2042021963 @default.
- W2584222766 cites W2045409727 @default.
- W2584222766 cites W2045728711 @default.
- W2584222766 cites W2049193892 @default.
- W2584222766 cites W2051776099 @default.
- W2584222766 cites W2054856852 @default.
- W2584222766 cites W2056832177 @default.
- W2584222766 cites W2059337036 @default.
- W2584222766 cites W2059471477 @default.
- W2584222766 cites W2062525878 @default.
- W2584222766 cites W2064518113 @default.
- W2584222766 cites W2075002003 @default.
- W2584222766 cites W2075698740 @default.
- W2584222766 cites W2078504022 @default.
- W2584222766 cites W2079331158 @default.
- W2584222766 cites W2079560417 @default.
- W2584222766 cites W2081528639 @default.
- W2584222766 cites W2081933919 @default.
- W2584222766 cites W2085028214 @default.
- W2584222766 cites W2086020590 @default.
- W2584222766 cites W2092916024 @default.
- W2584222766 cites W2096285477 @default.
- W2584222766 cites W2097000949 @default.
- W2584222766 cites W2099739687 @default.
- W2584222766 cites W2101135654 @default.
- W2584222766 cites W2105837661 @default.
- W2584222766 cites W2107932899 @default.
- W2584222766 cites W2110344505 @default.
- W2584222766 cites W2113121748 @default.
- W2584222766 cites W2113758182 @default.
- W2584222766 cites W2115094738 @default.
- W2584222766 cites W2117591375 @default.
- W2584222766 cites W2118219290 @default.
- W2584222766 cites W2118913692 @default.
- W2584222766 cites W2122180295 @default.
- W2584222766 cites W2123220482 @default.
- W2584222766 cites W2125179509 @default.
- W2584222766 cites W2129566263 @default.
- W2584222766 cites W2136330412 @default.