FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2584240963> ?p ?o ?g. }

• W2584240963 endingPage "2538" @default.
• W2584240963 startingPage "2524" @default.
• W2584240963 abstract "The mechanisms that govern node of Ranvier organization, stability, and long-term maintenance remain to be fully elucidated. One of the molecular components of the node is the cytoskeletal scaffolding protein, ankyrin G (AnkG), which interacts with multiple members of the nodal complex. The role of AnkG in nodal organization and maintenance is still not clearly defined as to whether AnkG functions as an initial nodal organizer or whether it functions as a nodal stabilizer after the nodal complex has been assembled. Using a mouse model system, we report here that perinatal and juvenile neuronal ablation of AnkG has differential consequences on nodal stability. Early loss of AnkG creates immature nodes with abnormal morphology, which undergo accelerated destabilization within a month, resulting in rapid voltage-gated sodium (NaV) channel and βIV spectrin loss with reduced effects on neurofascin 186. On the other hand, late ablation of AnkG from established nodal complexes leads to slow but progressive nodal destabilization over 10 months, primarily affecting βIV spectrin, followed by NaV channels, with modest impact on neurofascin 186. We also show that ankyrin R and βI spectrin are not sufficient to prevent nodal disorganization after AnkG ablation. Additionally, nodal disorganization in both early and late AnkG mutants is accompanied by axonal pathology and neurological dysfunction. Together, our results suggest that AnkG plays an indispensable role in the maturation and long-term stabilization of the newly assembled nodal complex, and that loss of AnkG after nodal stabilization does not lead to rapid nodal disassembly but to loss of specific nodal components in a time-dependent manner.SIGNIFICANCE STATEMENT Nodes of Ranvier are the myelin-free gaps along myelinated axons that allow fast communication between neurons and their target cells by propagating action potentials in a saltatory manner. The cytoskeletal scaffolding protein ankyrin G (AnkG) has been thought to play an important role in node formation; however, its precise role in nodal assembly, stability, and maintenance is still not clear. By using spatiotemporal ablation of AnkG, we report its differential role in nodal maturation and stabilization. We show that early AnkG-deficient nodes fail to mature and undergo rapid destabilization. In contrast, nodes that assemble with AnkG are much more stable and undergo gradual disintegration with sequential loss of nodal components in the absence of AnkG." @default.
• W2584240963 created "2017-02-10" @default.
• W2584240963 creator A5060418630 @default.
• W2584240963 creator A5065959288 @default.
• W2584240963 creator A5072480918 @default.
• W2584240963 date "2017-02-01" @default.
• W2584240963 modified "2023-10-17" @default.
• W2584240963 title "Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons" @default.
• W2584240963 cites W1585222504 @default.
• W2584240963 cites W1606121092 @default.
• W2584240963 cites W1606137504 @default.
• W2584240963 cites W190406931 @default.
• W2584240963 cites W1963622047 @default.
• W2584240963 cites W1965545778 @default.
• W2584240963 cites W1973904714 @default.
• W2584240963 cites W1978553600 @default.
• W2584240963 cites W1982110038 @default.
• W2584240963 cites W1998139699 @default.
• W2584240963 cites W2000485285 @default.
• W2584240963 cites W2008113469 @default.
• W2584240963 cites W2009129481 @default.
• W2584240963 cites W2012961395 @default.
• W2584240963 cites W2015565810 @default.
• W2584240963 cites W2016352795 @default.
• W2584240963 cites W2017281603 @default.
• W2584240963 cites W2033435068 @default.
• W2584240963 cites W2034442917 @default.
• W2584240963 cites W2040310469 @default.
• W2584240963 cites W2046086535 @default.
• W2584240963 cites W2048430961 @default.
• W2584240963 cites W2056897764 @default.
• W2584240963 cites W2059812088 @default.
• W2584240963 cites W2060466579 @default.
• W2584240963 cites W2061842603 @default.
• W2584240963 cites W2069700766 @default.
• W2584240963 cites W2070880712 @default.
• W2584240963 cites W2071271986 @default.
• W2584240963 cites W2073135856 @default.
• W2584240963 cites W2076393292 @default.
• W2584240963 cites W2077843597 @default.
• W2584240963 cites W2079735011 @default.
• W2584240963 cites W2099863332 @default.
• W2584240963 cites W2102246439 @default.
• W2584240963 cites W2115628640 @default.
• W2584240963 cites W2118478594 @default.
• W2584240963 cites W2128922463 @default.
• W2584240963 cites W2132369818 @default.
• W2584240963 cites W2138261127 @default.
• W2584240963 cites W2142703154 @default.
• W2584240963 cites W2143699287 @default.
• W2584240963 cites W2149834909 @default.
• W2584240963 cites W2152059298 @default.
• W2584240963 cites W2164425582 @default.
• W2584240963 cites W2415595698 @default.
• W2584240963 doi "https://doi.org/10.1523/jneurosci.2661-16.2017" @default.
• W2584240963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5354314" @default.
• W2584240963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28148727" @default.
• W2584240963 hasPublicationYear "2017" @default.
• W2584240963 type Work @default.
• W2584240963 sameAs 2584240963 @default.
• W2584240963 citedByCount "24" @default.
• W2584240963 countsByYear W25842409632017 @default.
• W2584240963 countsByYear W25842409632018 @default.
• W2584240963 countsByYear W25842409632019 @default.
• W2584240963 countsByYear W25842409632020 @default.
• W2584240963 countsByYear W25842409632022 @default.
• W2584240963 crossrefType "journal-article" @default.
• W2584240963 hasAuthorship W2584240963A5060418630 @default.
• W2584240963 hasAuthorship W2584240963A5065959288 @default.
• W2584240963 hasAuthorship W2584240963A5072480918 @default.
• W2584240963 hasBestOaLocation W25842409631 @default.
• W2584240963 hasConcept C104317684 @default.
• W2584240963 hasConcept C105702510 @default.
• W2584240963 hasConcept C142669718 @default.
• W2584240963 hasConcept C1491633281 @default.
• W2584240963 hasConcept C169760540 @default.
• W2584240963 hasConcept C182800266 @default.
• W2584240963 hasConcept C2777037019 @default.
• W2584240963 hasConcept C2778609137 @default.
• W2584240963 hasConcept C50244902 @default.
• W2584240963 hasConcept C529278444 @default.
• W2584240963 hasConcept C54355233 @default.
• W2584240963 hasConcept C83330619 @default.
• W2584240963 hasConcept C86803240 @default.
• W2584240963 hasConcept C95444343 @default.
• W2584240963 hasConceptScore W2584240963C104317684 @default.
• W2584240963 hasConceptScore W2584240963C105702510 @default.
• W2584240963 hasConceptScore W2584240963C142669718 @default.
• W2584240963 hasConceptScore W2584240963C1491633281 @default.
• W2584240963 hasConceptScore W2584240963C169760540 @default.
• W2584240963 hasConceptScore W2584240963C182800266 @default.
• W2584240963 hasConceptScore W2584240963C2777037019 @default.
• W2584240963 hasConceptScore W2584240963C2778609137 @default.
• W2584240963 hasConceptScore W2584240963C50244902 @default.
• W2584240963 hasConceptScore W2584240963C529278444 @default.
• W2584240963 hasConceptScore W2584240963C54355233 @default.
• W2584240963 hasConceptScore W2584240963C83330619 @default.
• W2584240963 hasConceptScore W2584240963C86803240 @default.

• next