Matches in SemOpenAlex for { <https://semopenalex.org/work/W2584451192> ?p ?o ?g. }
- W2584451192 endingPage "881.e6" @default.
- W2584451192 startingPage "867" @default.
- W2584451192 abstract "Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is poorly understood. We developed novel genetically encoded ER-targeted low-affinity Ca2+ indicators optimized for examining axonal ER Ca2+. Our experiments revealed that presynaptic function is tightly controlled by ER Ca2+ content. We found that neuronal activity drives net Ca2+ uptake into presynaptic ER although this activity does not contribute significantly to shaping cytosolic Ca2+ except during prolonged repetitive firing. In contrast, we found that axonal ER acts as an actuator of plasma membrane (PM) function: [Ca2+]ER controls STIM1 activation in presynaptic terminals, which results in the local modulation of presynaptic function, impacting activity-driven Ca2+ entry and release probability. These experiments reveal a critical role of presynaptic ER in the control of neurotransmitter release and will help frame future investigations into the molecular basis of ER-driven neuronal disease states." @default.
- W2584451192 created "2017-02-10" @default.
- W2584451192 creator A5005601864 @default.
- W2584451192 creator A5008547059 @default.
- W2584451192 creator A5019160089 @default.
- W2584451192 creator A5057776991 @default.
- W2584451192 creator A5058624570 @default.
- W2584451192 creator A5079931540 @default.
- W2584451192 date "2017-02-01" @default.
- W2584451192 modified "2023-10-14" @default.
- W2584451192 title "Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals" @default.
- W2584451192 cites W117864132 @default.
- W2584451192 cites W1542263802 @default.
- W2584451192 cites W1587103517 @default.
- W2584451192 cites W1642181682 @default.
- W2584451192 cites W1857299654 @default.
- W2584451192 cites W1858453603 @default.
- W2584451192 cites W1924188120 @default.
- W2584451192 cites W1966467373 @default.
- W2584451192 cites W1966795480 @default.
- W2584451192 cites W1967646152 @default.
- W2584451192 cites W1967949819 @default.
- W2584451192 cites W1969071483 @default.
- W2584451192 cites W1974830274 @default.
- W2584451192 cites W1974888639 @default.
- W2584451192 cites W1978593035 @default.
- W2584451192 cites W1978842225 @default.
- W2584451192 cites W1985452716 @default.
- W2584451192 cites W1988314408 @default.
- W2584451192 cites W1990811410 @default.
- W2584451192 cites W1992166970 @default.
- W2584451192 cites W1994123659 @default.
- W2584451192 cites W1997759034 @default.
- W2584451192 cites W1999739054 @default.
- W2584451192 cites W2001175917 @default.
- W2584451192 cites W2001917660 @default.
- W2584451192 cites W2010179451 @default.
- W2584451192 cites W2012458221 @default.
- W2584451192 cites W2012508686 @default.
- W2584451192 cites W2013077952 @default.
- W2584451192 cites W2019023589 @default.
- W2584451192 cites W2026919047 @default.
- W2584451192 cites W2030017066 @default.
- W2584451192 cites W2031958964 @default.
- W2584451192 cites W2032351311 @default.
- W2584451192 cites W2032562864 @default.
- W2584451192 cites W2033673006 @default.
- W2584451192 cites W2035820077 @default.
- W2584451192 cites W2038901812 @default.
- W2584451192 cites W2039346189 @default.
- W2584451192 cites W2039907396 @default.
- W2584451192 cites W2041677049 @default.
- W2584451192 cites W2042850387 @default.
- W2584451192 cites W2043714441 @default.
- W2584451192 cites W2044643187 @default.
- W2584451192 cites W2051661723 @default.
- W2584451192 cites W2056142956 @default.
- W2584451192 cites W2060907832 @default.
- W2584451192 cites W2067678773 @default.
- W2584451192 cites W2068571139 @default.
- W2584451192 cites W2077591858 @default.
- W2584451192 cites W2079074254 @default.
- W2584451192 cites W2080897541 @default.
- W2584451192 cites W2088491939 @default.
- W2584451192 cites W2088605279 @default.
- W2584451192 cites W2089157578 @default.
- W2584451192 cites W2091694654 @default.
- W2584451192 cites W2092364585 @default.
- W2584451192 cites W2096199252 @default.
- W2584451192 cites W2105092954 @default.
- W2584451192 cites W2110105381 @default.
- W2584451192 cites W2113975825 @default.
- W2584451192 cites W2114637214 @default.
- W2584451192 cites W2117018607 @default.
- W2584451192 cites W2122054000 @default.
- W2584451192 cites W2122216266 @default.
- W2584451192 cites W2128489958 @default.
- W2584451192 cites W2137508826 @default.
- W2584451192 cites W2145835877 @default.
- W2584451192 cites W2161210718 @default.
- W2584451192 cites W2163836090 @default.
- W2584451192 cites W2167036095 @default.
- W2584451192 cites W2169854908 @default.
- W2584451192 cites W2171332611 @default.
- W2584451192 cites W2171876349 @default.
- W2584451192 cites W2291957660 @default.
- W2584451192 cites W2318022761 @default.
- W2584451192 cites W2318697978 @default.
- W2584451192 cites W887843573 @default.
- W2584451192 doi "https://doi.org/10.1016/j.neuron.2017.01.010" @default.
- W2584451192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5325711" @default.
- W2584451192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28162809" @default.
- W2584451192 hasPublicationYear "2017" @default.
- W2584451192 type Work @default.
- W2584451192 sameAs 2584451192 @default.
- W2584451192 citedByCount "198" @default.
- W2584451192 countsByYear W25844511922017 @default.
- W2584451192 countsByYear W25844511922018 @default.