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• W2584656768 abstract "The impact of immunosuppression on interferon-γ release assays and novel cytokine biomarkers of TB infection, mycobacteria-specific IL-2, IP-10 and TNF-α responses was investigated in an ex vivo model. Cytokine responses in standard QuantiFERON-TB Gold in-Tube (QFT-GIT) assays were compared with duplicate assays containing dexamethasone or infliximab. Dexamethasone converted QFT-GIT results from positive to negative in 30% of participants. Antigen-stimulated interferon-γ, IL-2 and TNF-α responses were markedly reduced, but IP-10 responses were preserved. Infliximab caused QFT-GIT result conversion in up to 30% of participants and substantial reductions in all cytokine responses. Therefore, corticosteroids and anti-TNF-α agents significantly impair interferon-γ release assay performance. IP-10 may be a more robust TB biomarker than interferon-γ in patients receiving corticosteroids." @default.
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• W2584656768 date "2017-02-03" @default.
• W2584656768 modified "2023-10-11" @default.
• W2584656768 title "Corticosteroids and infliximab impair the performance of interferon-γ release assays used for diagnosis of latent tuberculosis" @default.
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• W2584656768 doi "https://doi.org/10.1136/thoraxjnl-2016-209397" @default.
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