FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2584675521> ?p ?o ?g. }

• W2584675521 endingPage "15801" @default.
• W2584675521 startingPage "15789" @default.
• W2584675521 abstract "The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation in BC has been explored. The methylation status of three CpG sites in the CHL1 promoter was analysed by pyrosequencing in neoplastic biopsies from 142 patients with invasive BC and compared with that of non-neoplastic tissues. We found higher CHL1 methylation levels in breast tumours than in non-neoplastic tissues, either from mammoplasties or adjacent-to-tumour, which correlated with lower levels of protein expression in tumours measured by immunohistochemistry. A panel of five BC cell lines was treated with two epigenetic drugs, and restoration of CHL1 expression was observed, indicating in vitro dynamic epigenetic regulation. CHL1 was silenced by shRNA in immortalized but non-neoplastic mammary cells, and enhanced cell proliferation and migration, but not invasion, were found by real-time cell analysis. The prognostic value of CHL1 hypermethylation was assessed by the log-rank test and fitted in a Cox regression model. Importantly, CHL1 hypermethylation was very significantly associated with shorter progression-free survival in our BC patient series, independent of age and stage (p = 0.001). In conclusion, our results indicate that CHL1 is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in BC." @default.
• W2584675521 created "2017-02-10" @default.
• W2584675521 creator A5003072475 @default.
• W2584675521 creator A5005489053 @default.
• W2584675521 creator A5010137759 @default.
• W2584675521 creator A5010739738 @default.
• W2584675521 creator A5013933481 @default.
• W2584675521 creator A5026560400 @default.
• W2584675521 creator A5051307105 @default.
• W2584675521 creator A5052833522 @default.
• W2584675521 creator A5062071343 @default.
• W2584675521 creator A5063726212 @default.
• W2584675521 creator A5075422488 @default.
• W2584675521 creator A5080540302 @default.
• W2584675521 creator A5086531116 @default.
• W2584675521 creator A5091638762 @default.
• W2584675521 date "2017-02-02" @default.
• W2584675521 modified "2023-10-06" @default.
• W2584675521 title "<i>CHL1</i> hypermethylation as a potential biomarker of poor prognosis in breast cancer" @default.
• W2584675521 cites W1529243395 @default.
• W2584675521 cites W1575004765 @default.
• W2584675521 cites W1681030413 @default.
• W2584675521 cites W1857779813 @default.
• W2584675521 cites W1869304578 @default.
• W2584675521 cites W1933892142 @default.
• W2584675521 cites W1949370810 @default.
• W2584675521 cites W1973767578 @default.
• W2584675521 cites W1976845229 @default.
• W2584675521 cites W2010539731 @default.
• W2584675521 cites W2021769991 @default.
• W2584675521 cites W2033748513 @default.
• W2584675521 cites W2034594496 @default.
• W2584675521 cites W2035411102 @default.
• W2584675521 cites W2049016817 @default.
• W2584675521 cites W2053442386 @default.
• W2584675521 cites W2074124878 @default.
• W2584675521 cites W2098775844 @default.
• W2584675521 cites W2112780046 @default.
• W2584675521 cites W2117775530 @default.
• W2584675521 cites W2127057139 @default.
• W2584675521 cites W2128458647 @default.
• W2584675521 cites W2134520863 @default.
• W2584675521 cites W2138188580 @default.
• W2584675521 cites W2151549305 @default.
• W2584675521 cites W2156132570 @default.
• W2584675521 cites W2156180077 @default.
• W2584675521 cites W2160382927 @default.
• W2584675521 cites W2161770015 @default.
• W2584675521 cites W2167325961 @default.
• W2584675521 cites W2174947044 @default.
• W2584675521 cites W2176164901 @default.
• W2584675521 cites W2181001755 @default.
• W2584675521 cites W2209655256 @default.
• W2584675521 cites W2275066906 @default.
• W2584675521 cites W2397209014 @default.
• W2584675521 cites W2413750348 @default.
• W2584675521 cites W2462874715 @default.
• W2584675521 cites W2918113740 @default.
• W2584675521 cites W4243667708 @default.
• W2584675521 cites W4252714226 @default.
• W2584675521 doi "https://doi.org/10.18632/oncotarget.15004" @default.
• W2584675521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5362523" @default.
• W2584675521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28178655" @default.
• W2584675521 hasPublicationYear "2017" @default.
• W2584675521 type Work @default.
• W2584675521 sameAs 2584675521 @default.
• W2584675521 citedByCount "31" @default.
• W2584675521 countsByYear W25846755212017 @default.
• W2584675521 countsByYear W25846755212018 @default.
• W2584675521 countsByYear W25846755212019 @default.
• W2584675521 countsByYear W25846755212020 @default.
• W2584675521 countsByYear W25846755212021 @default.
• W2584675521 countsByYear W25846755212022 @default.
• W2584675521 countsByYear W25846755212023 @default.
• W2584675521 crossrefType "journal-article" @default.
• W2584675521 hasAuthorship W2584675521A5003072475 @default.
• W2584675521 hasAuthorship W2584675521A5005489053 @default.
• W2584675521 hasAuthorship W2584675521A5010137759 @default.
• W2584675521 hasAuthorship W2584675521A5010739738 @default.
• W2584675521 hasAuthorship W2584675521A5013933481 @default.
• W2584675521 hasAuthorship W2584675521A5026560400 @default.
• W2584675521 hasAuthorship W2584675521A5051307105 @default.
• W2584675521 hasAuthorship W2584675521A5052833522 @default.
• W2584675521 hasAuthorship W2584675521A5062071343 @default.
• W2584675521 hasAuthorship W2584675521A5063726212 @default.
• W2584675521 hasAuthorship W2584675521A5075422488 @default.
• W2584675521 hasAuthorship W2584675521A5080540302 @default.
• W2584675521 hasAuthorship W2584675521A5086531116 @default.
• W2584675521 hasAuthorship W2584675521A5091638762 @default.
• W2584675521 hasBestOaLocation W25846755211 @default.
• W2584675521 hasConcept C104317684 @default.
• W2584675521 hasConcept C121608353 @default.
• W2584675521 hasConcept C140173407 @default.
• W2584675521 hasConcept C142724271 @default.
• W2584675521 hasConcept C150194340 @default.
• W2584675521 hasConcept C190727270 @default.
• W2584675521 hasConcept C203014093 @default.
• W2584675521 hasConcept C204232928 @default.

• next