Matches in SemOpenAlex for { <https://semopenalex.org/work/W258482907> ?p ?o ?g. }
- W258482907 abstract "Previous studies demonstrated that NELL-1 promoted osteogenic differentiation of bone marrowl stromal cells (BMSCs). BMSC differentiation into osteoblasts and the signaling pathways involved are poorly understood. We hypothesized that NELL-1 binds to Integrin and promotes osteogenic differentiation through FAK signaling pathway. To test this hypothesis, we examined the physical interaction of NELL-1 with Integrin beta-1 and inhibition of NELL-1's cell binding and adhesion using knockdown of Integrin beta-1 siRNA. We also assayed for phosphorylation of FAK as well as expression of osteogenic differentiation markers (OCN, OPN, ALP staining) and adiopogenic differentiation markers (ORO staining) in BMSC. We found that NELL-1 physically binds to Integrin beta-1 and Integrin beta-1 siRNA knockdown reduced NELL-1 cell binding significantly. NELL-1 stimulated expression of Integrin beta-1 and activated FAK phosphorylation. Finally, NELL-1 enhanced expression of osteogenic genes, whereas it inhibited expression of adiopogenic genes. Taken together, our results suggest that NELL-1 may initiates transduction signals through Integrin, and FAK pathway may play an important role in regulating NELL-1 induced osteogenic and adipogenic differentiation of BMSC." @default.
- W258482907 created "2016-06-24" @default.
- W258482907 creator A5076567585 @default.
- W258482907 date "2012-01-01" @default.
- W258482907 modified "2023-09-24" @default.
- W258482907 title "NELL-1 regulates BMSC osteogenic and adipogenic differentiation by interacting with Integrin and regulating cell focal adhesion" @default.
- W258482907 cites W1507752960 @default.
- W258482907 cites W1569589651 @default.
- W258482907 cites W1576773659 @default.
- W258482907 cites W1663371441 @default.
- W258482907 cites W1963555074 @default.
- W258482907 cites W1963826107 @default.
- W258482907 cites W1966241193 @default.
- W258482907 cites W1967402039 @default.
- W258482907 cites W1973663950 @default.
- W258482907 cites W1976620205 @default.
- W258482907 cites W1983426119 @default.
- W258482907 cites W1988150665 @default.
- W258482907 cites W1988502218 @default.
- W258482907 cites W1989783456 @default.
- W258482907 cites W1993871444 @default.
- W258482907 cites W1994923386 @default.
- W258482907 cites W1997812904 @default.
- W258482907 cites W1999145684 @default.
- W258482907 cites W2003098906 @default.
- W258482907 cites W2005986476 @default.
- W258482907 cites W2006056970 @default.
- W258482907 cites W2011490281 @default.
- W258482907 cites W2019624169 @default.
- W258482907 cites W2021705436 @default.
- W258482907 cites W2022407580 @default.
- W258482907 cites W2024059382 @default.
- W258482907 cites W2025553912 @default.
- W258482907 cites W2026303920 @default.
- W258482907 cites W2027379276 @default.
- W258482907 cites W2028691987 @default.
- W258482907 cites W2029145815 @default.
- W258482907 cites W2031066958 @default.
- W258482907 cites W2039686664 @default.
- W258482907 cites W2044895919 @default.
- W258482907 cites W2046216255 @default.
- W258482907 cites W2047368765 @default.
- W258482907 cites W2050457057 @default.
- W258482907 cites W2054566768 @default.
- W258482907 cites W2056301653 @default.
- W258482907 cites W2063962898 @default.
- W258482907 cites W2066367871 @default.
- W258482907 cites W2079595896 @default.
- W258482907 cites W2086543433 @default.
- W258482907 cites W2092233035 @default.
- W258482907 cites W2095115114 @default.
- W258482907 cites W2095152292 @default.
- W258482907 cites W2096232808 @default.
- W258482907 cites W2102455595 @default.
- W258482907 cites W2103198077 @default.
- W258482907 cites W2105183595 @default.
- W258482907 cites W2106697461 @default.
- W258482907 cites W2107813460 @default.
- W258482907 cites W2119413986 @default.
- W258482907 cites W2125272276 @default.
- W258482907 cites W2130635700 @default.
- W258482907 cites W2132411277 @default.
- W258482907 cites W2132620372 @default.
- W258482907 cites W2134080046 @default.
- W258482907 cites W2135577930 @default.
- W258482907 cites W2143658021 @default.
- W258482907 cites W2146313456 @default.
- W258482907 cites W2147073902 @default.
- W258482907 cites W2154192697 @default.
- W258482907 cites W2155882794 @default.
- W258482907 cites W2163829418 @default.
- W258482907 cites W2165253648 @default.
- W258482907 cites W75660270 @default.
- W258482907 hasPublicationYear "2012" @default.
- W258482907 type Work @default.
- W258482907 sameAs 258482907 @default.
- W258482907 citedByCount "0" @default.
- W258482907 crossrefType "journal-article" @default.
- W258482907 hasAuthorship W258482907A5076567585 @default.
- W258482907 hasConcept C104317684 @default.
- W258482907 hasConcept C11960822 @default.
- W258482907 hasConcept C122927707 @default.
- W258482907 hasConcept C148738053 @default.
- W258482907 hasConcept C1491633281 @default.
- W258482907 hasConcept C151166631 @default.
- W258482907 hasConcept C153911025 @default.
- W258482907 hasConcept C16930146 @default.
- W258482907 hasConcept C173396325 @default.
- W258482907 hasConcept C185592680 @default.
- W258482907 hasConcept C195687474 @default.
- W258482907 hasConcept C198826908 @default.
- W258482907 hasConcept C502942594 @default.
- W258482907 hasConcept C54355233 @default.
- W258482907 hasConcept C55493867 @default.
- W258482907 hasConcept C62478195 @default.
- W258482907 hasConcept C81885089 @default.
- W258482907 hasConcept C85789140 @default.
- W258482907 hasConcept C86803240 @default.
- W258482907 hasConcept C95444343 @default.
- W258482907 hasConceptScore W258482907C104317684 @default.