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• W2585069912 abstract "Objectives: To determine whether the length of gonadotropin stimulation during IVF-ET cycles plays a role in determining pregnancy outcomes. Methods: 172 cycles of patients undergoing IVF-ET with controlled ovarian hyperstimulation (COH) in the period were analyzed. Patients underwent standard protocols using gonadotropins and embryo transfer was done on day 3 or day 5 after oocyte retrieval. Baseline day 3 estradiol and FSH levels were drawn prior to stimulation cycles to assess ovarian reserve. Clinical pregnancy was confirmed sonographically with embryonic heartbeat. Good ovarian reserve was defined by estradiol < 50 pg/ml and FSH <10 mIU/ml. Chi square analysis was used to determine the clinical pregnancy rate compared to days of stimulation. Paired student t-test was used to compare total, pregnant, and non-pregnant cycles with number of days of stimulation in patients with good and poor ovarian reserve. Pearson’s correlation was used to analyze the fertilization rate compared with the number of days of gonadotropin stimulation. Results: 1. There was no correlation between the number of days of gonadotropin stimulation and the number of eggs retrieved or the fertilization rate (p=.55 and .93 respectively). 2. There was no difference in the number of clinical pregnancies achieved when comparing the number of days of stimulation received from 7 days to 14 days. Tabled 1Days of StimulationClinical Pregnancy RateDays of StimulationClinical Pregnancy Ratep-value<80≥8.30.11<9.32≥9.24.46<10.29≥10.23.52<11.26≥11.29.81<12.28≥12.20.60<13.28≥13.13.34<14.28≥140.22 Open table in a new tab 3. Although a negative trend was apparent, there was no significant correlation between day 3 estradiol levels and the number of days of gonadotropin stimulation required during IVF-ET cycles (p=.16). 4. There was a positive correlation between day 3 FSH levels and the number of days of gonadotropin stimulation required during IVF-ET cycles (p=.009). 5. There was no difference in the mean number of days of stimulation received between patients with good and poor ovarian reserve when comparing their overall, pregnant, and non-pregnant cycles Tabled 1Good responders (days of stimulation + Std)Poor responders (days of stimulation + Std)P-valueTotal9.3 ± 1.610.0 ± 2.6.21Pregnant9.6 ± 1.69.0 ± 1.4.15Non-pregnant9.1 ± 1.510.2 ± 2.8.53 Open table in a new tab Conclusion: 1. The length of gonadotropin stimulation does not impact clinical pregnancy outcome in IVF-ET cycle (includes number of eggs retrieved, fertilization rate, and clinical pregnancy rates). 2. Extremes of stimulation duration (<8 and>12 days) do not demonstrate adverse outcomes. 3. Higher baseline FSH levels were associated with longer stimulation cycles. 4. There is no significant difference in the length of stimulation between patients with good and poor ovarian reserve." @default.
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• W2585069912 date "2006-04-01" @default.
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• W2585069912 title "P-24" @default.
• W2585069912 doi "https://doi.org/10.1016/j.fertnstert.2006.02.039" @default.
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