Matches in SemOpenAlex for { <https://semopenalex.org/work/W2585123485> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2585123485 endingPage "127a" @default.
- W2585123485 startingPage "127a" @default.
- W2585123485 abstract "The dopamine transporter (DAT) belongs to the neurotransmitter/sodium symporter (NSS) family of membrane proteins that are responsible for reuptake of neurotransmitters from the synaptic cleft to terminate a neuronal signal and enable subsequent neurotransmitter release from the presynaptic neuron. The release of one sodium ion from the crystallographically determined sodium binding site Na2 had been identified as an initial step in the transport cycle which prepares the transporter for substrate translocation by stabilizing an inward-open conformation. We have constructed Markov State Models (MSMs) from extensive molecular dynamics simulations of human DAT (hDAT) to explore the mechanism of this sodium release. Our results quantify the release process triggered by hydration of the Na2 site that occurs concomitantly with a conformational transition from an outward-facing to an inward-facing state of the transporter. The kinetics of the release process are computed from the MSM, and transition path theory is used to identify the most probable sodium release pathways. An intermediate state is discovered on the sodium release pathway, and the results reveal the importance of various modes of interaction of the N-terminus of hDAT in controlling the pathways of release." @default.
- W2585123485 created "2017-02-10" @default.
- W2585123485 creator A5014370221 @default.
- W2585123485 creator A5036364992 @default.
- W2585123485 creator A5087154415 @default.
- W2585123485 date "2017-02-01" @default.
- W2585123485 modified "2023-09-28" @default.
- W2585123485 title "Markov State-Based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter" @default.
- W2585123485 doi "https://doi.org/10.1016/j.bpj.2016.11.707" @default.
- W2585123485 hasPublicationYear "2017" @default.
- W2585123485 type Work @default.
- W2585123485 sameAs 2585123485 @default.
- W2585123485 citedByCount "0" @default.
- W2585123485 crossrefType "journal-article" @default.
- W2585123485 hasAuthorship W2585123485A5014370221 @default.
- W2585123485 hasAuthorship W2585123485A5036364992 @default.
- W2585123485 hasAuthorship W2585123485A5087154415 @default.
- W2585123485 hasBestOaLocation W25851234851 @default.
- W2585123485 hasConcept C104317684 @default.
- W2585123485 hasConcept C120405084 @default.
- W2585123485 hasConcept C121332964 @default.
- W2585123485 hasConcept C12554922 @default.
- W2585123485 hasConcept C148898269 @default.
- W2585123485 hasConcept C149011108 @default.
- W2585123485 hasConcept C16696662 @default.
- W2585123485 hasConcept C169760540 @default.
- W2585123485 hasConcept C170493617 @default.
- W2585123485 hasConcept C178790620 @default.
- W2585123485 hasConcept C185592680 @default.
- W2585123485 hasConcept C2775864247 @default.
- W2585123485 hasConcept C2776219046 @default.
- W2585123485 hasConcept C2776755682 @default.
- W2585123485 hasConcept C2909816965 @default.
- W2585123485 hasConcept C2993285035 @default.
- W2585123485 hasConcept C50952357 @default.
- W2585123485 hasConcept C513476851 @default.
- W2585123485 hasConcept C537181965 @default.
- W2585123485 hasConcept C55493867 @default.
- W2585123485 hasConcept C62520636 @default.
- W2585123485 hasConcept C86803240 @default.
- W2585123485 hasConcept C99631742 @default.
- W2585123485 hasConceptScore W2585123485C104317684 @default.
- W2585123485 hasConceptScore W2585123485C120405084 @default.
- W2585123485 hasConceptScore W2585123485C121332964 @default.
- W2585123485 hasConceptScore W2585123485C12554922 @default.
- W2585123485 hasConceptScore W2585123485C148898269 @default.
- W2585123485 hasConceptScore W2585123485C149011108 @default.
- W2585123485 hasConceptScore W2585123485C16696662 @default.
- W2585123485 hasConceptScore W2585123485C169760540 @default.
- W2585123485 hasConceptScore W2585123485C170493617 @default.
- W2585123485 hasConceptScore W2585123485C178790620 @default.
- W2585123485 hasConceptScore W2585123485C185592680 @default.
- W2585123485 hasConceptScore W2585123485C2775864247 @default.
- W2585123485 hasConceptScore W2585123485C2776219046 @default.
- W2585123485 hasConceptScore W2585123485C2776755682 @default.
- W2585123485 hasConceptScore W2585123485C2909816965 @default.
- W2585123485 hasConceptScore W2585123485C2993285035 @default.
- W2585123485 hasConceptScore W2585123485C50952357 @default.
- W2585123485 hasConceptScore W2585123485C513476851 @default.
- W2585123485 hasConceptScore W2585123485C537181965 @default.
- W2585123485 hasConceptScore W2585123485C55493867 @default.
- W2585123485 hasConceptScore W2585123485C62520636 @default.
- W2585123485 hasConceptScore W2585123485C86803240 @default.
- W2585123485 hasConceptScore W2585123485C99631742 @default.
- W2585123485 hasIssue "3" @default.
- W2585123485 hasLocation W25851234851 @default.
- W2585123485 hasLocation W25851234852 @default.
- W2585123485 hasOpenAccess W2585123485 @default.
- W2585123485 hasPrimaryLocation W25851234851 @default.
- W2585123485 hasRelatedWork W2081646467 @default.
- W2585123485 hasRelatedWork W2083674889 @default.
- W2585123485 hasRelatedWork W2084515195 @default.
- W2585123485 hasRelatedWork W2568664960 @default.
- W2585123485 hasRelatedWork W2584629806 @default.
- W2585123485 hasRelatedWork W2585123485 @default.
- W2585123485 hasRelatedWork W2914877487 @default.
- W2585123485 hasRelatedWork W2951064616 @default.
- W2585123485 hasRelatedWork W3211191554 @default.
- W2585123485 hasRelatedWork W4225371759 @default.
- W2585123485 hasVolume "112" @default.
- W2585123485 isParatext "false" @default.
- W2585123485 isRetracted "false" @default.
- W2585123485 magId "2585123485" @default.
- W2585123485 workType "article" @default.