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• W2585163301 abstract "Abstract Heterotetramer voltage-gated K + (K V ) channels K V 2.1/K V 6.4 display a gating charge-voltage (Q V ) distribution composed by two separate components. We use state dependent chemical accessibility to cysteines substituted in either K V 2.1 or K V 6.4 to assess the voltage sensor movements of each subunit. By comparing the voltage dependences of chemical modification and gating charge displacement, here we show that each gating charge component corresponds to a specific subunit forming the heterotetramer. The voltage sensors from K V 6.4 subunits move at more negative potentials than the voltage sensors belonging to K V 2.1 subunits. These results indicate that the voltage sensors from the tetrameric channels move independently. In addition, our data shows that 75% of the total charge is attributed to K V 2.1, while 25% to K V 6.4. Thus, the most parsimonious model for K V 2.1/K V 6.4 channels’ stoichiometry is 3:1." @default.
• W2585163301 created "2017-02-10" @default.
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• W2585163301 date "2017-01-31" @default.
• W2585163301 modified "2023-09-26" @default.
• W2585163301 title "Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers" @default.
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• W2585163301 doi "https://doi.org/10.1038/srep41646" @default.
• W2585163301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5282584" @default.
• W2585163301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28139741" @default.
• W2585163301 hasPublicationYear "2017" @default.
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