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- W2585207291 abstract "Receptor tyrosine kinases (RTKs) are known to be key regulators of cancer cell proliferation, migration, invasion and metastatic spread. Ligand-binding to the extracellular domain triggers canonical activation of the intracellular tyrosine kinase domain. In contrast, it has become evident that RTKs are also regulated by non-canonical tyrosine kinase-independent mechanisms via phosphorylation of their serine/threonine residues. In this review, I mainly introduce our recent findings on the non-canonical regulation of epidermal growth factor receptor (EGFR), ErbB2 and erythropoietin-producing hepatocellular receptor A2 (EphA2), and discuss the roles of non-canonical activation of RTKs in cancer progression and resistance to targeted cancer agents. Further characterization of non-canonical regulation will contribute to the development of new target cancer therapies." @default.
- W2585207291 created "2017-02-10" @default.
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- W2585207291 date "2017-02-01" @default.
- W2585207291 modified "2023-10-05" @default.
- W2585207291 title "Non-canonical Activation of Receptor Tyrosine Kinases in Cancer Progression" @default.
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- W2585207291 doi "https://doi.org/10.1248/yakushi.16-00229-4" @default.
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