FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2585278833> ?p ?o ?g. }

• W2585278833 endingPage "524" @default.
• W2585278833 startingPage "521" @default.
• W2585278833 abstract "Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain barrier (BBB) permeability, and increasing neurogenesis in the hippocampus although not completely to youthful levels. Other aging-associated parameters, such as reduced synaptic density, are not affected, suggesting that anti-aging therapeutics may be further optimized. Montelukast targets leukotriene receptors GPR17 and CysLTR1 and appears to invert leukotriene signaling, converting an inflammatory signal into an anti-inflammatory signal. This acts as a dominant factor to overcome the dysfunctional effects of aging reportedly mediated, in part, by blood-borne factors such as beta-2 microglobulin that inhibit neurogenesis in the dentate gyrus of the hippocampus. The key mechanism for cognitive improvement by montelukast may be restoration of BBB integrity, which would presumably decrease the amount of deleterious blood-borne factors to enter the brain. Whether or not this hypothesis is true for montelukast, drugs that restore or maintain BBB integrity may be useful in combating age-related loss of cognitive function." @default.
• W2585278833 created "2017-02-10" @default.
• W2585278833 creator A5045978150 @default.
• W2585278833 creator A5078237390 @default.
• W2585278833 date "2016-12-01" @default.
• W2585278833 modified "2023-09-26" @default.
• W2585278833 title "Pharmaceutical Rejuvenation of Age-Associated Decline in Spatial Memory" @default.
• W2585278833 cites W1832678746 @default.
• W2585278833 cites W1834814630 @default.
• W2585278833 cites W1965306647 @default.
• W2585278833 cites W1968280132 @default.
• W2585278833 cites W1969905245 @default.
• W2585278833 cites W1973240518 @default.
• W2585278833 cites W1978927200 @default.
• W2585278833 cites W2004525117 @default.
• W2585278833 cites W2019249853 @default.
• W2585278833 cites W2027990732 @default.
• W2585278833 cites W2028408087 @default.
• W2585278833 cites W2031861879 @default.
• W2585278833 cites W2067028731 @default.
• W2585278833 cites W2071496001 @default.
• W2585278833 cites W2076832548 @default.
• W2585278833 cites W2079684474 @default.
• W2585278833 cites W2082360677 @default.
• W2585278833 cites W2082414904 @default.
• W2585278833 cites W2097971052 @default.
• W2585278833 cites W2101853437 @default.
• W2585278833 cites W2122494325 @default.
• W2585278833 cites W2128640727 @default.
• W2585278833 cites W2143455502 @default.
• W2585278833 cites W2145235967 @default.
• W2585278833 cites W2182436270 @default.
• W2585278833 cites W2245266827 @default.
• W2585278833 cites W2296186628 @default.
• W2585278833 cites W2330493936 @default.
• W2585278833 cites W2550166770 @default.
• W2585278833 doi "https://doi.org/10.1089/rej.2016.1903" @default.
• W2585278833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27881050" @default.
• W2585278833 hasPublicationYear "2016" @default.
• W2585278833 type Work @default.
• W2585278833 sameAs 2585278833 @default.
• W2585278833 citedByCount "6" @default.
• W2585278833 countsByYear W25852788332017 @default.
• W2585278833 countsByYear W25852788332019 @default.
• W2585278833 countsByYear W25852788332021 @default.
• W2585278833 countsByYear W25852788332022 @default.
• W2585278833 crossrefType "journal-article" @default.
• W2585278833 hasAuthorship W2585278833A5045978150 @default.
• W2585278833 hasAuthorship W2585278833A5078237390 @default.
• W2585278833 hasConcept C126322002 @default.
• W2585278833 hasConcept C15744967 @default.
• W2585278833 hasConcept C169760540 @default.
• W2585278833 hasConcept C2776042228 @default.
• W2585278833 hasConcept C2776322731 @default.
• W2585278833 hasConcept C2776464000 @default.
• W2585278833 hasConcept C2776914184 @default.
• W2585278833 hasConcept C2778402981 @default.
• W2585278833 hasConcept C2779134260 @default.
• W2585278833 hasConcept C2779483572 @default.
• W2585278833 hasConcept C2781161787 @default.
• W2585278833 hasConcept C2984863031 @default.
• W2585278833 hasConcept C4746552 @default.
• W2585278833 hasConcept C529278444 @default.
• W2585278833 hasConcept C71924100 @default.
• W2585278833 hasConcept C87753298 @default.
• W2585278833 hasConceptScore W2585278833C126322002 @default.
• W2585278833 hasConceptScore W2585278833C15744967 @default.
• W2585278833 hasConceptScore W2585278833C169760540 @default.
• W2585278833 hasConceptScore W2585278833C2776042228 @default.
• W2585278833 hasConceptScore W2585278833C2776322731 @default.
• W2585278833 hasConceptScore W2585278833C2776464000 @default.
• W2585278833 hasConceptScore W2585278833C2776914184 @default.
• W2585278833 hasConceptScore W2585278833C2778402981 @default.
• W2585278833 hasConceptScore W2585278833C2779134260 @default.
• W2585278833 hasConceptScore W2585278833C2779483572 @default.
• W2585278833 hasConceptScore W2585278833C2781161787 @default.
• W2585278833 hasConceptScore W2585278833C2984863031 @default.
• W2585278833 hasConceptScore W2585278833C4746552 @default.
• W2585278833 hasConceptScore W2585278833C529278444 @default.
• W2585278833 hasConceptScore W2585278833C71924100 @default.
• W2585278833 hasConceptScore W2585278833C87753298 @default.
• W2585278833 hasIssue "6" @default.
• W2585278833 hasLocation W25852788331 @default.
• W2585278833 hasLocation W25852788332 @default.
• W2585278833 hasOpenAccess W2585278833 @default.
• W2585278833 hasPrimaryLocation W25852788331 @default.
• W2585278833 hasRelatedWork W1499468620 @default.
• W2585278833 hasRelatedWork W1979782640 @default.
• W2585278833 hasRelatedWork W1990962744 @default.
• W2585278833 hasRelatedWork W2025258306 @default.
• W2585278833 hasRelatedWork W2062834116 @default.
• W2585278833 hasRelatedWork W2073424413 @default.
• W2585278833 hasRelatedWork W2081792644 @default.
• W2585278833 hasRelatedWork W2585278833 @default.
• W2585278833 hasRelatedWork W2610549804 @default.
• W2585278833 hasRelatedWork W2770383780 @default.
• W2585278833 hasVolume "19" @default.
• W2585278833 isParatext "false" @default.

• next