FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2585384470> ?p ?o ?g. }

• W2585384470 endingPage "1165" @default.
• W2585384470 startingPage "1155" @default.
• W2585384470 abstract "Murraya koenigii (curry tree) leaves are rich in bioactive compounds such as flavonoids, alkaloids, and coumarins. Alkaloids from M. koenigii leaves have antianalgesic, antiulcerogenic, antiobesity, and antitumor activities. In this study, we tested the cytotoxic and proteasome-inhibitory potential of a total alkaloid extract (TAE) from M. koenigii leaves in the breast cancer cell line MDA-MB-231. The TAE decreased cell viability with an IC50 of 14.4 μg/mL and altered growth kinetics of breast cancer cells. TAE (32 μg/mL) arrested cells (35%) in the “S” phase of the cell cycle and induced apoptosis. The 26S proteasome, a multicatalytic protease complex, promotes tumor cell proliferation and protects tumor cells from apoptosis. The TAE and mahanine, a carbazole alkaloid present in M. koenigii leaves, preferentially inhibited the trypsin-like, but not the chymotrypsin-like proteolytic activity of the proteasome with an IC50 of 162 μg/mL and 287 μM, respectively. In silico analysis of 26 compounds from M. koenigii leaves revealed significant docking scores for mahanine and two other carbazole alkaloids with the β2 and β5 subunits of the catalytic 20S proteasome. Taken together, this study demonstrates that inhibition of the proteasome is an important biological activity of M. koenigii alkaloids, which may lead to cancer cell death." @default.
• W2585384470 created "2017-02-10" @default.
• W2585384470 creator A5028580968 @default.
• W2585384470 creator A5039744815 @default.
• W2585384470 creator A5047666780 @default.
• W2585384470 creator A5057297353 @default.
• W2585384470 creator A5062491554 @default.
• W2585384470 creator A5065838864 @default.
• W2585384470 date "2016-12-01" @default.
• W2585384470 modified "2023-10-11" @default.
• W2585384470 title "Cytotoxicity and Proteasome Inhibition by Alkaloid Extract from <i>Murraya koenigii</i> Leaves in Breast Cancer Cells—Molecular Docking Studies" @default.
• W2585384470 cites W1914280947 @default.
• W2585384470 cites W1975640846 @default.
• W2585384470 cites W1992692251 @default.
• W2585384470 cites W1998526530 @default.
• W2585384470 cites W1999119754 @default.
• W2585384470 cites W2020777107 @default.
• W2585384470 cites W2021159172 @default.
• W2585384470 cites W2021613218 @default.
• W2585384470 cites W2024300266 @default.
• W2585384470 cites W2034689201 @default.
• W2585384470 cites W2055418221 @default.
• W2585384470 cites W2058049213 @default.
• W2585384470 cites W2065480848 @default.
• W2585384470 cites W2073387664 @default.
• W2585384470 cites W2089613837 @default.
• W2585384470 cites W2104187864 @default.
• W2585384470 cites W2113067867 @default.
• W2585384470 cites W2121196991 @default.
• W2585384470 cites W2136255144 @default.
• W2585384470 cites W2148372281 @default.
• W2585384470 cites W2163495162 @default.
• W2585384470 cites W2320883114 @default.
• W2585384470 cites W2405021105 @default.
• W2585384470 doi "https://doi.org/10.1089/jmf.2016.3767" @default.
• W2585384470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27982755" @default.
• W2585384470 hasPublicationYear "2016" @default.
• W2585384470 type Work @default.
• W2585384470 sameAs 2585384470 @default.
• W2585384470 citedByCount "16" @default.
• W2585384470 countsByYear W25853844702017 @default.
• W2585384470 countsByYear W25853844702018 @default.
• W2585384470 countsByYear W25853844702020 @default.
• W2585384470 countsByYear W25853844702021 @default.
• W2585384470 countsByYear W25853844702022 @default.
• W2585384470 countsByYear W25853844702023 @default.
• W2585384470 crossrefType "journal-article" @default.
• W2585384470 hasAuthorship W2585384470A5028580968 @default.
• W2585384470 hasAuthorship W2585384470A5039744815 @default.
• W2585384470 hasAuthorship W2585384470A5047666780 @default.
• W2585384470 hasAuthorship W2585384470A5057297353 @default.
• W2585384470 hasAuthorship W2585384470A5062491554 @default.
• W2585384470 hasAuthorship W2585384470A5065838864 @default.
• W2585384470 hasConcept C109316439 @default.
• W2585384470 hasConcept C121608353 @default.
• W2585384470 hasConcept C159110408 @default.
• W2585384470 hasConcept C185592680 @default.
• W2585384470 hasConcept C190283241 @default.
• W2585384470 hasConcept C202751555 @default.
• W2585384470 hasConcept C27740335 @default.
• W2585384470 hasConcept C2777667214 @default.
• W2585384470 hasConcept C2778539424 @default.
• W2585384470 hasConcept C41685203 @default.
• W2585384470 hasConcept C53227056 @default.
• W2585384470 hasConcept C54355233 @default.
• W2585384470 hasConcept C55493867 @default.
• W2585384470 hasConcept C556039675 @default.
• W2585384470 hasConcept C59822182 @default.
• W2585384470 hasConcept C62112901 @default.
• W2585384470 hasConcept C71240020 @default.
• W2585384470 hasConcept C71924100 @default.
• W2585384470 hasConcept C86803240 @default.
• W2585384470 hasConcept C96232424 @default.
• W2585384470 hasConcept C98274493 @default.
• W2585384470 hasConceptScore W2585384470C109316439 @default.
• W2585384470 hasConceptScore W2585384470C121608353 @default.
• W2585384470 hasConceptScore W2585384470C159110408 @default.
• W2585384470 hasConceptScore W2585384470C185592680 @default.
• W2585384470 hasConceptScore W2585384470C190283241 @default.
• W2585384470 hasConceptScore W2585384470C202751555 @default.
• W2585384470 hasConceptScore W2585384470C27740335 @default.
• W2585384470 hasConceptScore W2585384470C2777667214 @default.
• W2585384470 hasConceptScore W2585384470C2778539424 @default.
• W2585384470 hasConceptScore W2585384470C41685203 @default.
• W2585384470 hasConceptScore W2585384470C53227056 @default.
• W2585384470 hasConceptScore W2585384470C54355233 @default.
• W2585384470 hasConceptScore W2585384470C55493867 @default.
• W2585384470 hasConceptScore W2585384470C556039675 @default.
• W2585384470 hasConceptScore W2585384470C59822182 @default.
• W2585384470 hasConceptScore W2585384470C62112901 @default.
• W2585384470 hasConceptScore W2585384470C71240020 @default.
• W2585384470 hasConceptScore W2585384470C71924100 @default.
• W2585384470 hasConceptScore W2585384470C86803240 @default.
• W2585384470 hasConceptScore W2585384470C96232424 @default.
• W2585384470 hasConceptScore W2585384470C98274493 @default.
• W2585384470 hasIssue "12" @default.
• W2585384470 hasLocation W25853844701 @default.
• W2585384470 hasLocation W25853844702 @default.

• next