FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2585450916> ?p ?o ?g. }

• W2585450916 endingPage "158" @default.
• W2585450916 startingPage "148" @default.
• W2585450916 abstract "MicroRNA-363-3p (miR-363-3p) reportedly plays crucial roles in tumor development and progression in many types of cancers. However, its role in papillary thyroid carcinoma (PTC) remain largely unclear. We therefore investigated the function and underlying mechanism of miR-363-3p in PTC. Here, we found that miR-363-3p was significantly downregulated in human PTC tissue samples and cell lines, and that miR-363-3p levels are negatively correlated with advanced clinical stage and lymph node metastasis. In addition to suppressing tumor growth in vivo, restoration of miR-363-3p in TPC-1 cells significantly inhibits proliferation, migration, and invasion and induced apoptosis in vitro. Mechanistically, miR-363-3p was verified to directly bind to 3'UTR of the phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) mRNA, and reduce its expression at both mRNA and protein levels, which further inhibits phosphatidylinositol 3-kinase/Akt signaling pathway. PIK3CA expression was also found to be increased in human PTC tissues, and were inversely correlated with miR-363-3p. Furthermore, restoration of PIK3CA partially rescued the miR-363-3p-induced inhibition effect on TPC-1 cell proliferation, migration and invasion. Taken together, these findings indicated for the first time that miR-363-3p functions as a tumor suppressor in PTC, and its suppressive effect is mediated by repressing PIK3CA." @default.
• W2585450916 created "2017-02-10" @default.
• W2585450916 creator A5057117256 @default.
• W2585450916 creator A5066887020 @default.
• W2585450916 creator A5081675173 @default.
• W2585450916 creator A5085120246 @default.
• W2585450916 creator A5091168983 @default.
• W2585450916 date "2017-01-01" @default.
• W2585450916 modified "2023-09-29" @default.
• W2585450916 title "MicroRNA-363-3p inhibits papillary thyroid carcinoma progression by targeting PIK3CA." @default.
• W2585450916 cites W1607603286 @default.
• W2585450916 cites W1652682392 @default.
• W2585450916 cites W1938240656 @default.
• W2585450916 cites W1973676369 @default.
• W2585450916 cites W1975304818 @default.
• W2585450916 cites W1985746903 @default.
• W2585450916 cites W1987201457 @default.
• W2585450916 cites W2020065640 @default.
• W2585450916 cites W2026697437 @default.
• W2585450916 cites W2051928563 @default.
• W2585450916 cites W2061360944 @default.
• W2585450916 cites W2076609845 @default.
• W2585450916 cites W2095443834 @default.
• W2585450916 cites W2096368274 @default.
• W2585450916 cites W2140634215 @default.
• W2585450916 cites W2151306153 @default.
• W2585450916 cites W2166499650 @default.
• W2585450916 cites W2283885217 @default.
• W2585450916 cites W2336945046 @default.
• W2585450916 cites W2345994426 @default.
• W2585450916 cites W2397584071 @default.
• W2585450916 cites W2429335438 @default.
• W2585450916 cites W2470900586 @default.
• W2585450916 cites W2471071054 @default.
• W2585450916 cites W2518407064 @default.
• W2585450916 cites W2522882125 @default.
• W2585450916 cites W2548643352 @default.
• W2585450916 cites W2552099953 @default.
• W2585450916 cites W2557304967 @default.
• W2585450916 cites W4237011200 @default.
• W2585450916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5250689" @default.
• W2585450916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28123856" @default.
• W2585450916 hasPublicationYear "2017" @default.
• W2585450916 type Work @default.
• W2585450916 sameAs 2585450916 @default.
• W2585450916 citedByCount "19" @default.
• W2585450916 countsByYear W25854509162017 @default.
• W2585450916 countsByYear W25854509162018 @default.
• W2585450916 countsByYear W25854509162019 @default.
• W2585450916 countsByYear W25854509162020 @default.
• W2585450916 countsByYear W25854509162021 @default.
• W2585450916 countsByYear W25854509162022 @default.
• W2585450916 crossrefType "journal-article" @default.
• W2585450916 hasAuthorship W2585450916A5057117256 @default.
• W2585450916 hasAuthorship W2585450916A5066887020 @default.
• W2585450916 hasAuthorship W2585450916A5081675173 @default.
• W2585450916 hasAuthorship W2585450916A5085120246 @default.
• W2585450916 hasAuthorship W2585450916A5091168983 @default.
• W2585450916 hasConcept C104317684 @default.
• W2585450916 hasConcept C121608353 @default.
• W2585450916 hasConcept C126322002 @default.
• W2585450916 hasConcept C134018914 @default.
• W2585450916 hasConcept C145059251 @default.
• W2585450916 hasConcept C179185449 @default.
• W2585450916 hasConcept C184235292 @default.
• W2585450916 hasConcept C185592680 @default.
• W2585450916 hasConcept C2779013556 @default.
• W2585450916 hasConcept C2781465904 @default.
• W2585450916 hasConcept C2993294228 @default.
• W2585450916 hasConcept C502942594 @default.
• W2585450916 hasConcept C526584372 @default.
• W2585450916 hasConcept C54355233 @default.
• W2585450916 hasConcept C55493867 @default.
• W2585450916 hasConcept C62112901 @default.
• W2585450916 hasConcept C62478195 @default.
• W2585450916 hasConcept C71924100 @default.
• W2585450916 hasConcept C75217442 @default.
• W2585450916 hasConcept C86554907 @default.
• W2585450916 hasConcept C86803240 @default.
• W2585450916 hasConcept C95444343 @default.
• W2585450916 hasConceptScore W2585450916C104317684 @default.
• W2585450916 hasConceptScore W2585450916C121608353 @default.
• W2585450916 hasConceptScore W2585450916C126322002 @default.
• W2585450916 hasConceptScore W2585450916C134018914 @default.
• W2585450916 hasConceptScore W2585450916C145059251 @default.
• W2585450916 hasConceptScore W2585450916C179185449 @default.
• W2585450916 hasConceptScore W2585450916C184235292 @default.
• W2585450916 hasConceptScore W2585450916C185592680 @default.
• W2585450916 hasConceptScore W2585450916C2779013556 @default.
• W2585450916 hasConceptScore W2585450916C2781465904 @default.
• W2585450916 hasConceptScore W2585450916C2993294228 @default.
• W2585450916 hasConceptScore W2585450916C502942594 @default.
• W2585450916 hasConceptScore W2585450916C526584372 @default.
• W2585450916 hasConceptScore W2585450916C54355233 @default.
• W2585450916 hasConceptScore W2585450916C55493867 @default.
• W2585450916 hasConceptScore W2585450916C62112901 @default.
• W2585450916 hasConceptScore W2585450916C62478195 @default.
• W2585450916 hasConceptScore W2585450916C71924100 @default.

• next