FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2585655283> ?p ?o ?g. }

• W2585655283 endingPage "522" @default.
• W2585655283 startingPage "514" @default.
• W2585655283 abstract "Prime objective of this research work was to the improve efficacy of a BCS class II drug, nabumetone (NBM). Nanostructured lipid carrier (NLC) of NBM was developed using melt-emulsification and ultrasonication technique. Prior to the formulation development, screening of various solid lipids, liquid lipids and surfactants were done and the most suitable excipients were selected. The NLC formulation was optimized using Box-Behnken Design Expert® software. For optimization purpose, independent variables were taken as % lipid mix, % surfactant and sonication time (minute). Particle size, PDI and entrapment efficiency were selected as dependent variables. The optimized formulation was characterized using photon correlation spectroscopy and was found with 127 ± 1.75 nm average particle size and 0.279 ± 0.016 polydispersity index (PDI). When observed under TEM and SEM, NLC particles were found with nearly spherical shape and particle size of NLC in this study almost matched with the average particle size determined by photon correlation spectroscopy. In DSC thermogram of NBM-NLC, the endothermic peak of the drug at 84.04 °C was disappeared that means drug was fully dissolved in lipid. In vitro release study of developed formulation showed burst release followed by slow diffusion based sustained release. The pharmacodynamic study shows better anti-inflammatory effect (almost 2 times) when compared with NBM suspension. Based on the data obtained from the in vitro and in vivo studies it was concluded that NLC can be a promising carrier and helps in improving intestinal absorption of orally administered NBM." @default.
• W2585655283 created "2017-02-10" @default.
• W2585655283 creator A5011064718 @default.
• W2585655283 creator A5017778560 @default.
• W2585655283 creator A5031165199 @default.
• W2585655283 creator A5035538154 @default.
• W2585655283 creator A5043811356 @default.
• W2585655283 creator A5064337706 @default.
• W2585655283 creator A5089261501 @default.
• W2585655283 date "2017-04-01" @default.
• W2585655283 modified "2023-09-30" @default.
• W2585655283 title "Development of nabumetone loaded lipid nano-scaffold for the effective oral delivery; optimization, characterization, drug release and pharmacodynamic study" @default.
• W2585655283 cites W1968006521 @default.
• W2585655283 cites W1972309781 @default.
• W2585655283 cites W1978803685 @default.
• W2585655283 cites W1981468523 @default.
• W2585655283 cites W1989495132 @default.
• W2585655283 cites W1993061546 @default.
• W2585655283 cites W1996897622 @default.
• W2585655283 cites W2011920500 @default.
• W2585655283 cites W2013567835 @default.
• W2585655283 cites W2017317942 @default.
• W2585655283 cites W2017917394 @default.
• W2585655283 cites W2019355258 @default.
• W2585655283 cites W2020975942 @default.
• W2585655283 cites W2025722135 @default.
• W2585655283 cites W2033784479 @default.
• W2585655283 cites W2040369667 @default.
• W2585655283 cites W2048423840 @default.
• W2585655283 cites W2048745449 @default.
• W2585655283 cites W2054727211 @default.
• W2585655283 cites W2057083263 @default.
• W2585655283 cites W2064161366 @default.
• W2585655283 cites W2067575165 @default.
• W2585655283 cites W2072259978 @default.
• W2585655283 cites W2077112332 @default.
• W2585655283 cites W2094968130 @default.
• W2585655283 cites W2109624279 @default.
• W2585655283 cites W2139443876 @default.
• W2585655283 cites W2147883214 @default.
• W2585655283 cites W2151823004 @default.
• W2585655283 cites W2161051443 @default.
• W2585655283 cites W2171245233 @default.
• W2585655283 cites W2263666717 @default.
• W2585655283 cites W2343039489 @default.
• W2585655283 cites W2343182168 @default.
• W2585655283 cites W2526289642 @default.
• W2585655283 doi "https://doi.org/10.1016/j.molliq.2017.01.107" @default.
• W2585655283 hasPublicationYear "2017" @default.
• W2585655283 type Work @default.
• W2585655283 sameAs 2585655283 @default.
• W2585655283 citedByCount "22" @default.
• W2585655283 countsByYear W25856552832017 @default.
• W2585655283 countsByYear W25856552832018 @default.
• W2585655283 countsByYear W25856552832019 @default.
• W2585655283 countsByYear W25856552832020 @default.
• W2585655283 countsByYear W25856552832021 @default.
• W2585655283 countsByYear W25856552832023 @default.
• W2585655283 crossrefType "journal-article" @default.
• W2585655283 hasAuthorship W2585655283A5011064718 @default.
• W2585655283 hasAuthorship W2585655283A5017778560 @default.
• W2585655283 hasAuthorship W2585655283A5031165199 @default.
• W2585655283 hasAuthorship W2585655283A5035538154 @default.
• W2585655283 hasAuthorship W2585655283A5043811356 @default.
• W2585655283 hasAuthorship W2585655283A5064337706 @default.
• W2585655283 hasAuthorship W2585655283A5089261501 @default.
• W2585655283 hasConcept C104628117 @default.
• W2585655283 hasConcept C11432220 @default.
• W2585655283 hasConcept C147789679 @default.
• W2585655283 hasConcept C150903083 @default.
• W2585655283 hasConcept C171250308 @default.
• W2585655283 hasConcept C178790620 @default.
• W2585655283 hasConcept C185592680 @default.
• W2585655283 hasConcept C187530423 @default.
• W2585655283 hasConcept C192562407 @default.
• W2585655283 hasConcept C207001950 @default.
• W2585655283 hasConcept C2779820397 @default.
• W2585655283 hasConcept C43617362 @default.
• W2585655283 hasConcept C55493867 @default.
• W2585655283 hasConcept C58226133 @default.
• W2585655283 hasConcept C86803240 @default.
• W2585655283 hasConceptScore W2585655283C104628117 @default.
• W2585655283 hasConceptScore W2585655283C11432220 @default.
• W2585655283 hasConceptScore W2585655283C147789679 @default.
• W2585655283 hasConceptScore W2585655283C150903083 @default.
• W2585655283 hasConceptScore W2585655283C171250308 @default.
• W2585655283 hasConceptScore W2585655283C178790620 @default.
• W2585655283 hasConceptScore W2585655283C185592680 @default.
• W2585655283 hasConceptScore W2585655283C187530423 @default.
• W2585655283 hasConceptScore W2585655283C192562407 @default.
• W2585655283 hasConceptScore W2585655283C207001950 @default.
• W2585655283 hasConceptScore W2585655283C2779820397 @default.
• W2585655283 hasConceptScore W2585655283C43617362 @default.
• W2585655283 hasConceptScore W2585655283C55493867 @default.
• W2585655283 hasConceptScore W2585655283C58226133 @default.
• W2585655283 hasConceptScore W2585655283C86803240 @default.
• W2585655283 hasFunder F4320320736 @default.
• W2585655283 hasLocation W25856552831 @default.

• next