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- W2585655367 startingPage "458" @default.
- W2585655367 abstract "The hypothalamic neuropeptide oxytocin (OT) has received increasing attention for its role in modulating social-emotional processes across species. Previous studies on using intranasal-OT in humans point to a crucial engagement of the amygdala in the observed neuromodulatory effects of OT under task and rest conditions. However, the amygdala is not a single homogenous structure, but rather a set of structurally and functionally heterogeneous nuclei that show distinct patterns of connectivity with limbic and frontal emotion-processing regions. To determine potential differential effects of OT on functional connectivity of the amygdala subregions, 79 male participants underwent resting-state fMRI following randomized intranasal-OT or placebo administration. In line with previous studies OT increased the connectivity of the total amygdala with dorso-medial prefrontal regions engaged in emotion regulation. In addition, OT enhanced coupling of the total amygdala with cerebellar regions. Importantly, OT differentially altered the connectivity of amygdala subregions with distinct up-stream cortical nodes, particularly prefrontal/parietal, and cerebellar down-stream regions. OT-induced increased connectivity with cerebellar regions were largely driven by effects on the centromedial and basolateral subregions, whereas increased connectivity with prefrontal regions were largely mediated by right superficial and basolateral subregions. OT decreased connectivity of the centromedial subregions with core hubs of the emotional face processing network in temporal, occipital and parietal regions. Preliminary findings suggest that effects on the superficial amygdala-prefrontal pathway were inversely associated with levels of subclinical depression, possibly indicating that OT modulation may be blunted in the context of increased pathological load. Together, the present findings suggest a subregional-specific modulatory role of OT on amygdala-centered emotion processing networks in humans." @default.
- W2585655367 created "2017-02-10" @default.
- W2585655367 creator A5000445902 @default.
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- W2585655367 creator A5048132181 @default.
- W2585655367 creator A5079364906 @default.
- W2585655367 date "2017-04-01" @default.
- W2585655367 modified "2023-10-05" @default.
- W2585655367 title "Oxytocin differentially alters resting state functional connectivity between amygdala subregions and emotional control networks: Inverse correlation with depressive traits" @default.
- W2585655367 cites W1144617745 @default.
- W2585655367 cites W1530553393 @default.
- W2585655367 cites W1536234704 @default.
- W2585655367 cites W1546369842 @default.
- W2585655367 cites W1562123410 @default.
- W2585655367 cites W1606961096 @default.
- W2585655367 cites W1921511099 @default.
- W2585655367 cites W1948687830 @default.
- W2585655367 cites W1965231812 @default.
- W2585655367 cites W1968237538 @default.
- W2585655367 cites W1968315111 @default.
- W2585655367 cites W1972927639 @default.
- W2585655367 cites W1973561392 @default.
- W2585655367 cites W1976872417 @default.
- W2585655367 cites W1983458543 @default.
- W2585655367 cites W1984051795 @default.
- W2585655367 cites W1990134753 @default.
- W2585655367 cites W1998410431 @default.
- W2585655367 cites W1998872047 @default.
- W2585655367 cites W2000799395 @default.
- W2585655367 cites W2005336684 @default.
- W2585655367 cites W2011131455 @default.
- W2585655367 cites W2023426804 @default.
- W2585655367 cites W2024067798 @default.
- W2585655367 cites W2026454313 @default.
- W2585655367 cites W2036704889 @default.
- W2585655367 cites W2040170011 @default.
- W2585655367 cites W2042111121 @default.
- W2585655367 cites W2042214903 @default.
- W2585655367 cites W2046836290 @default.
- W2585655367 cites W2047453615 @default.
- W2585655367 cites W2050618347 @default.
- W2585655367 cites W2055559081 @default.
- W2585655367 cites W2058494291 @default.
- W2585655367 cites W2064029491 @default.
- W2585655367 cites W2064135174 @default.
- W2585655367 cites W2065623558 @default.
- W2585655367 cites W2071881327 @default.
- W2585655367 cites W2077718235 @default.
- W2585655367 cites W2078631866 @default.
- W2585655367 cites W2081718320 @default.
- W2585655367 cites W2084160531 @default.
- W2585655367 cites W2086146798 @default.
- W2585655367 cites W2086183175 @default.
- W2585655367 cites W2088980803 @default.
- W2585655367 cites W2099318103 @default.
- W2585655367 cites W2100819236 @default.
- W2585655367 cites W2102748276 @default.
- W2585655367 cites W2103264859 @default.
- W2585655367 cites W2106089606 @default.
- W2585655367 cites W2107408814 @default.
- W2585655367 cites W2113052000 @default.
- W2585655367 cites W2114429947 @default.
- W2585655367 cites W2121447055 @default.
- W2585655367 cites W2121748618 @default.
- W2585655367 cites W2121829192 @default.
- W2585655367 cites W2124725885 @default.
- W2585655367 cites W2125687194 @default.
- W2585655367 cites W2126334133 @default.
- W2585655367 cites W2129478806 @default.
- W2585655367 cites W2131449726 @default.
- W2585655367 cites W2136449688 @default.
- W2585655367 cites W2138094931 @default.
- W2585655367 cites W2141857412 @default.
- W2585655367 cites W2141965013 @default.
- W2585655367 cites W2142685441 @default.
- W2585655367 cites W2149212681 @default.
- W2585655367 cites W2150568714 @default.
- W2585655367 cites W2151670337 @default.
- W2585655367 cites W2156874786 @default.
- W2585655367 cites W2157607979 @default.
- W2585655367 cites W2159597393 @default.
- W2585655367 cites W2165173100 @default.
- W2585655367 cites W2167182003 @default.
- W2585655367 cites W2169787465 @default.
- W2585655367 cites W2235676486 @default.
- W2585655367 cites W2274252588 @default.
- W2585655367 cites W2288001033 @default.
- W2585655367 cites W2293876729 @default.
- W2585655367 cites W2298685505 @default.
- W2585655367 cites W2333435192 @default.
- W2585655367 cites W2403681849 @default.
- W2585655367 cites W2463712686 @default.
- W2585655367 cites W2513460492 @default.
- W2585655367 cites W4235770099 @default.
- W2585655367 cites W4239024596 @default.