Matches in SemOpenAlex for { <https://semopenalex.org/work/W2585683583> ?p ?o ?g. }
- W2585683583 endingPage "79" @default.
- W2585683583 startingPage "73" @default.
- W2585683583 abstract "Neuregulin1 (Nrg1) and its receptors ErbB are crucial for heart development and for adult heart structural maintenance and function and Nrg1 has been proposed for heart failure treatment. Infarct size is the major determinant of heart failure and the mechanism of action and the role of each ErbB receptor remain obscure, especially in the post-ischemic myocardium. We hypothesized that Nrg1 and ErbB are affected at transcriptional level early after ischemia/reperfusion (I/R) injury, and that the protective postconditioning procedure (PostC, brief cycles of ischemia/reperfusion carried out after a sustained ischemia) can influence this pathway.The Langendorff's heart was used as an ex-vivo model to mimic an I/R injury in the whole rat heart; after 30min of ischemia and 2h of reperfusion, with or without PostC, Nrg1 and ErbB expression were analysed by quantitative real-time PCR and Western blot. While no changes occur for ErbB2, ErbB4 and Nrg1, an increase of ErbB3 expression occurs after I/R injury, with and without PostC. However, I/R reduces ErbB3 protein, whereas PostC preserves it. An in vitro analysis with H9c2 cells exposed to redox-stress indicated that the transient over-expression of ErbB3 alone is able to increase cell survival (MTT assay), limiting mitochondrial dysfunction (JC-1 probe) and apoptotic signals (Bax/Bcl-2 ratio).This study suggests ErbB3 as a protective factor against death pathways activated by redox stress and supports an involvement of this receptor in the pro-survival responses." @default.
- W2585683583 created "2017-02-10" @default.
- W2585683583 creator A5006446931 @default.
- W2585683583 creator A5007175460 @default.
- W2585683583 creator A5024542459 @default.
- W2585683583 creator A5039063027 @default.
- W2585683583 creator A5040928352 @default.
- W2585683583 creator A5042861270 @default.
- W2585683583 creator A5045025514 @default.
- W2585683583 date "2017-04-01" @default.
- W2585683583 modified "2023-09-24" @default.
- W2585683583 title "Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress" @default.
- W2585683583 cites W1764376417 @default.
- W2585683583 cites W1815197835 @default.
- W2585683583 cites W1970893866 @default.
- W2585683583 cites W1976275744 @default.
- W2585683583 cites W1978632845 @default.
- W2585683583 cites W1980141913 @default.
- W2585683583 cites W1985762436 @default.
- W2585683583 cites W1987196222 @default.
- W2585683583 cites W1992332114 @default.
- W2585683583 cites W1993172175 @default.
- W2585683583 cites W1995527759 @default.
- W2585683583 cites W2000943794 @default.
- W2585683583 cites W2001416774 @default.
- W2585683583 cites W2002211489 @default.
- W2585683583 cites W2003861577 @default.
- W2585683583 cites W2011472119 @default.
- W2585683583 cites W2012195897 @default.
- W2585683583 cites W2012211200 @default.
- W2585683583 cites W2019889924 @default.
- W2585683583 cites W2022787088 @default.
- W2585683583 cites W2024020506 @default.
- W2585683583 cites W2032530563 @default.
- W2585683583 cites W2043347179 @default.
- W2585683583 cites W2045570557 @default.
- W2585683583 cites W2058441947 @default.
- W2585683583 cites W2070515279 @default.
- W2585683583 cites W2070727232 @default.
- W2585683583 cites W2079445038 @default.
- W2585683583 cites W2083486309 @default.
- W2585683583 cites W2085374859 @default.
- W2585683583 cites W2087126389 @default.
- W2585683583 cites W2090842782 @default.
- W2585683583 cites W2093152832 @default.
- W2585683583 cites W2094864993 @default.
- W2585683583 cites W2096662849 @default.
- W2585683583 cites W2109410038 @default.
- W2585683583 cites W2110609828 @default.
- W2585683583 cites W2120636426 @default.
- W2585683583 cites W2123206362 @default.
- W2585683583 cites W2126327835 @default.
- W2585683583 cites W2126960465 @default.
- W2585683583 cites W2131015734 @default.
- W2585683583 cites W2140105071 @default.
- W2585683583 cites W2154077173 @default.
- W2585683583 cites W2170341886 @default.
- W2585683583 cites W2042162902 @default.
- W2585683583 doi "https://doi.org/10.1016/j.ijcard.2017.01.122" @default.
- W2585683583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28162790" @default.
- W2585683583 hasPublicationYear "2017" @default.
- W2585683583 type Work @default.
- W2585683583 sameAs 2585683583 @default.
- W2585683583 citedByCount "13" @default.
- W2585683583 countsByYear W25856835832017 @default.
- W2585683583 countsByYear W25856835832018 @default.
- W2585683583 countsByYear W25856835832019 @default.
- W2585683583 countsByYear W25856835832020 @default.
- W2585683583 countsByYear W25856835832021 @default.
- W2585683583 countsByYear W25856835832022 @default.
- W2585683583 crossrefType "journal-article" @default.
- W2585683583 hasAuthorship W2585683583A5006446931 @default.
- W2585683583 hasAuthorship W2585683583A5007175460 @default.
- W2585683583 hasAuthorship W2585683583A5024542459 @default.
- W2585683583 hasAuthorship W2585683583A5039063027 @default.
- W2585683583 hasAuthorship W2585683583A5040928352 @default.
- W2585683583 hasAuthorship W2585683583A5042861270 @default.
- W2585683583 hasAuthorship W2585683583A5045025514 @default.
- W2585683583 hasConcept C104317684 @default.
- W2585683583 hasConcept C115456853 @default.
- W2585683583 hasConcept C126322002 @default.
- W2585683583 hasConcept C170493617 @default.
- W2585683583 hasConcept C2776151105 @default.
- W2585683583 hasConcept C2776415932 @default.
- W2585683583 hasConcept C2778560701 @default.
- W2585683583 hasConcept C2779251935 @default.
- W2585683583 hasConcept C2779438470 @default.
- W2585683583 hasConcept C2780114680 @default.
- W2585683583 hasConcept C541997718 @default.
- W2585683583 hasConcept C55493867 @default.
- W2585683583 hasConcept C71924100 @default.
- W2585683583 hasConcept C86803240 @default.
- W2585683583 hasConcept C98274493 @default.
- W2585683583 hasConceptScore W2585683583C104317684 @default.
- W2585683583 hasConceptScore W2585683583C115456853 @default.
- W2585683583 hasConceptScore W2585683583C126322002 @default.
- W2585683583 hasConceptScore W2585683583C170493617 @default.
- W2585683583 hasConceptScore W2585683583C2776151105 @default.