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• W2585689325 abstract "Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A. campestris L (AcEO) and to investigate the antiplatelet, antioxidant effects and the mechanisms of its vasorelaxant effect. The chemical composition of AcEO was elucidated using GC/MS analysis. Then, the antioxidant effect was tested on DPPH radical scavenging and on the prevention of β-carotene bleaching. The antiplatelet effect was performed on the presence of the platelet agonists: thrombin and ADP. The mechanism of action of the vasorelaxant effect was studied by using the cellular blockers specified to explore the involvement of NO/GC pathway and in the presence of calcium channels blockers and potassium channels blockers. AcEO is predominated by the volatiles: spathulenol, ß-eudesmol and p-cymene. The maximal antioxidant effect was obtained with the dose 2 mg/ml of AcEO. The dose 1 mg/ml of AcEO showed a maximum antiplatelet effect of, respectively 49.73% ±9.54 and 48.20% ±8.49 on thrombin and ADP. The vasorelaxation seems not to be mediated via NOS/GC pathway neither via the potassium channels. However, pretreatment with calcium channels blockers attenuated this effect, suggesting that the vasorelaxation is mediated via inhibition of L-type Ca2+ channels and the activation of SERCA pumps of reticulum plasma. This study confirms the antioxidant, antiplatelet and vasorelaxant effects of A.campestris L essential oil. However, the antihypertensive use of this oil should be further confirmed by the chemical fractionation and subsequent bio-guided assays." @default.
• W2585689325 created "2017-02-10" @default.
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• W2585689325 date "2017-01-31" @default.
• W2585689325 modified "2023-09-26" @default.
• W2585689325 title "Chemical composition, vasorelaxant, antioxidant and antiplatelet effects of essential oil of Artemisia campestris L. from Oriental Morocco" @default.
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• W2585689325 cites W1643585163 @default.
• W2585689325 cites W187608677 @default.
• W2585689325 cites W1945756248 @default.
• W2585689325 cites W1966499987 @default.
• W2585689325 cites W1968643624 @default.
• W2585689325 cites W1971336938 @default.
• W2585689325 cites W1973701795 @default.
• W2585689325 cites W1976364974 @default.
• W2585689325 cites W1976614326 @default.
• W2585689325 cites W1979535402 @default.
• W2585689325 cites W1980780844 @default.
• W2585689325 cites W1983086708 @default.
• W2585689325 cites W1990482492 @default.
• W2585689325 cites W1991649858 @default.
• W2585689325 cites W1994005583 @default.
• W2585689325 cites W1997521748 @default.
• W2585689325 cites W1999072776 @default.
• W2585689325 cites W2003546971 @default.
• W2585689325 cites W2006420622 @default.
• W2585689325 cites W2009062947 @default.
• W2585689325 cites W2009263467 @default.
• W2585689325 cites W2009899857 @default.
• W2585689325 cites W2013598121 @default.
• W2585689325 cites W2014169859 @default.
• W2585689325 cites W2015643153 @default.
• W2585689325 cites W2016106561 @default.
• W2585689325 cites W2017588233 @default.
• W2585689325 cites W2024718471 @default.
• W2585689325 cites W2025511423 @default.
• W2585689325 cites W2026179628 @default.
• W2585689325 cites W2026665725 @default.
• W2585689325 cites W2035814888 @default.
• W2585689325 cites W2037343350 @default.
• W2585689325 cites W2040088007 @default.
• W2585689325 cites W2041791733 @default.
• W2585689325 cites W2042298343 @default.
• W2585689325 cites W2046873712 @default.
• W2585689325 cites W2050908002 @default.
• W2585689325 cites W2052339374 @default.
• W2585689325 cites W2053528864 @default.
• W2585689325 cites W2054303465 @default.
• W2585689325 cites W2055267987 @default.
• W2585689325 cites W2062475374 @default.
• W2585689325 cites W2065715924 @default.
• W2585689325 cites W2072348601 @default.
• W2585689325 cites W2085078257 @default.
• W2585689325 cites W2086450622 @default.
• W2585689325 cites W2089827468 @default.
• W2585689325 cites W2089970080 @default.
• W2585689325 cites W2090513881 @default.
• W2585689325 cites W2092977773 @default.
• W2585689325 cites W2094989836 @default.
• W2585689325 cites W2098108865 @default.
• W2585689325 cites W2102447197 @default.
• W2585689325 cites W2115508204 @default.
• W2585689325 cites W2116487770 @default.
• W2585689325 cites W2122384948 @default.
• W2585689325 cites W2126624423 @default.
• W2585689325 cites W2139736590 @default.
• W2585689325 cites W2157352021 @default.
• W2585689325 cites W2169182236 @default.
• W2585689325 cites W2173290212 @default.
• W2585689325 cites W2174739675 @default.
• W2585689325 cites W2184570586 @default.
• W2585689325 cites W2220742431 @default.
• W2585689325 cites W2312674125 @default.
• W2585689325 cites W2313542015 @default.
• W2585689325 cites W2320127040 @default.
• W2585689325 cites W2323897426 @default.
• W2585689325 cites W2340476360 @default.
• W2585689325 cites W2401254756 @default.
• W2585689325 cites W2408770002 @default.
• W2585689325 cites W2591307438 @default.
• W2585689325 cites W3014906431 @default.
• W2585689325 cites W306634120 @default.
• W2585689325 cites W39145358 @default.
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• W2585689325 doi "https://doi.org/10.1186/s12906-017-1598-2" @default.
• W2585689325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5282690" @default.
• W2585689325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28143473" @default.
• W2585689325 hasPublicationYear "2017" @default.
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