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- W2585695141 abstract "Kinesin Eg5 is a plus-end-directed microtubule-based motor that is essential for bipolar spindle formation during eukaryotic cell division. As Eg5 overexpressed in various malignant tumors, it has been considered as a potential target for cancer treatment. Loop L5 of Eg5 is a key region determining ATPase activity and motor function. Photochromic molecules undergo reversible isomerization in response to ultraviolet and visible light irradiation. Azobenzene exhibits cis-trans isomerization upon UV and visible light irradiations. Spiropyran also shows spiro-merocyanine isomerization upon UV and visible light irradiations. We have previouly introduced photochromic molecules azobenzene derivatives or spiropyran derivatives into L5 and succeeded to control the Eg5 ATPase activity using light irradiation. In this study, we designed and synthesized a novel photochromic thiol reactive compounds composed of azobenzene and spiropyran derivatives, IASA in order to control the function of Eg5 photo reversibly. IASP undergoes reversible isomerization among different three states. UV and visible light irradiations induced Cis-Mero state and Trans-Spiro state, respectively. In the dark, IASP exhibited Trans-Mero state. Therefore, it is expected that the different isomer states of IASP at the incorporated functional site of Eg5 may induce different conformational change of Eg5 resulting alteration of Eg5 ATPase and motor activities. The isomerizations of IASA were monitored by measuring absorption spectra. IASA was incorporated into the reactive single cysteine residue of Eg5 mutant. We tried to examine the photo reversible alteration of ATPase activity of Eg5 modified with IASA." @default.
- W2585695141 created "2017-02-10" @default.
- W2585695141 creator A5049167958 @default.
- W2585695141 date "2017-02-01" @default.
- W2585695141 modified "2023-09-26" @default.
- W2585695141 title "Novel Photochromic Compound Composed of Azobenzene and Spiropyran to Control the Function of Kinesin Eg5" @default.
- W2585695141 doi "https://doi.org/10.1016/j.bpj.2016.11.1651" @default.
- W2585695141 hasPublicationYear "2017" @default.
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