FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2585774804> ?p ?o ?g. }

• W2585774804 abstract "CD73 (ecto-5′-nucleotidase) is implicated in the development of many types of cancer. CD73 inhibitors are currently being tested in clinical trials for the treatment of cancer. Understanding the molecular and cellular actions of CD73 inhibitors is the key to improving this line of therapy. Quantitative real-time PCR (qRT-PCR) was used to detect the expression of CD73 and miR-30a-5p; Western blot and immunohistochemical assays were used to investigate the levels of CD73 and other proteins. Flow cytometry was used to determine cell cycle stage and apoptosis. CCK-8 and clonogenic assays were used to investigate cell proliferation. Wound healing, migration and invasion assays were used to investigate the motility of cells. A lung carcinoma xenograft mouse model was used to investigate the in vivo effects of CD73 and miR-30a-5p. In the present study, we found that CD73 is overexpressed and miR-30a-5p is underexpressed in non-small cell lung cancer tissues compared with adjacent noncancerous. Further, we showed that CD73 is a direct target of miR-30a-5p by luciferase reporter assays, qRT-PCR and western blot analysis. We also found that overexpression of miR-30a-5p in these non-small cell lung cancer cell lines inhibited cell proliferation in vitro and in vivo. Moreover, the epithelial-to-mesenchymal phenotype was suppressed and cell migration and invasion were inhibited; these effects were brought about via the EGF signaling pathway. Our findings reveal a new post-transcriptional mechanism of CD73 regulation via miR-30a-5p and EGFR-related drug resistance in non-small cell lung cancer." @default.
• W2585774804 created "2017-02-10" @default.
• W2585774804 creator A5000432967 @default.
• W2585774804 creator A5013277464 @default.
• W2585774804 creator A5023826377 @default.
• W2585774804 creator A5038784500 @default.
• W2585774804 creator A5046407339 @default.
• W2585774804 creator A5054656489 @default.
• W2585774804 creator A5066659782 @default.
• W2585774804 creator A5068423502 @default.
• W2585774804 creator A5091553972 @default.
• W2585774804 date "2017-02-03" @default.
• W2585774804 modified "2023-10-16" @default.
• W2585774804 title "CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer" @default.
• W2585774804 cites W1674891863 @default.
• W2585774804 cites W1945293306 @default.
• W2585774804 cites W1947060780 @default.
• W2585774804 cites W1974059338 @default.
• W2585774804 cites W1976324983 @default.
• W2585774804 cites W1976875491 @default.
• W2585774804 cites W1977209251 @default.
• W2585774804 cites W1986345950 @default.
• W2585774804 cites W1998605742 @default.
• W2585774804 cites W2004704417 @default.
• W2585774804 cites W2011528645 @default.
• W2585774804 cites W2012853695 @default.
• W2585774804 cites W2022908394 @default.
• W2585774804 cites W2042711079 @default.
• W2585774804 cites W2044073319 @default.
• W2585774804 cites W2045755466 @default.
• W2585774804 cites W2051881409 @default.
• W2585774804 cites W2053537854 @default.
• W2585774804 cites W2055532721 @default.
• W2585774804 cites W2066502054 @default.
• W2585774804 cites W2069136292 @default.
• W2585774804 cites W2070830104 @default.
• W2585774804 cites W2070915732 @default.
• W2585774804 cites W2078899050 @default.
• W2585774804 cites W2079286299 @default.
• W2585774804 cites W2080830471 @default.
• W2585774804 cites W2086589092 @default.
• W2585774804 cites W2102844520 @default.
• W2585774804 cites W2106787323 @default.
• W2585774804 cites W2113661022 @default.
• W2585774804 cites W2126496132 @default.
• W2585774804 cites W2130979840 @default.
• W2585774804 cites W2132106503 @default.
• W2585774804 cites W2136528920 @default.
• W2585774804 cites W2139233049 @default.
• W2585774804 cites W2141643824 @default.
• W2585774804 cites W2150625345 @default.
• W2585774804 cites W2154551754 @default.
• W2585774804 cites W2171836441 @default.
• W2585774804 cites W2228177663 @default.
• W2585774804 cites W2272984102 @default.
• W2585774804 cites W2413429676 @default.
• W2585774804 doi "https://doi.org/10.1186/s12943-017-0591-1" @default.
• W2585774804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5291990" @default.
• W2585774804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28158983" @default.
• W2585774804 hasPublicationYear "2017" @default.
• W2585774804 type Work @default.
• W2585774804 sameAs 2585774804 @default.
• W2585774804 citedByCount "107" @default.
• W2585774804 countsByYear W25857748042017 @default.
• W2585774804 countsByYear W25857748042018 @default.
• W2585774804 countsByYear W25857748042019 @default.
• W2585774804 countsByYear W25857748042020 @default.
• W2585774804 countsByYear W25857748042021 @default.
• W2585774804 countsByYear W25857748042022 @default.
• W2585774804 countsByYear W25857748042023 @default.
• W2585774804 crossrefType "journal-article" @default.
• W2585774804 hasAuthorship W2585774804A5000432967 @default.
• W2585774804 hasAuthorship W2585774804A5013277464 @default.
• W2585774804 hasAuthorship W2585774804A5023826377 @default.
• W2585774804 hasAuthorship W2585774804A5038784500 @default.
• W2585774804 hasAuthorship W2585774804A5046407339 @default.
• W2585774804 hasAuthorship W2585774804A5054656489 @default.
• W2585774804 hasAuthorship W2585774804A5066659782 @default.
• W2585774804 hasAuthorship W2585774804A5068423502 @default.
• W2585774804 hasAuthorship W2585774804A5091553972 @default.
• W2585774804 hasBestOaLocation W25857748041 @default.
• W2585774804 hasConcept C104317684 @default.
• W2585774804 hasConcept C117262875 @default.
• W2585774804 hasConcept C142724271 @default.
• W2585774804 hasConcept C1491633281 @default.
• W2585774804 hasConcept C150903083 @default.
• W2585774804 hasConcept C153911025 @default.
• W2585774804 hasConcept C190283241 @default.
• W2585774804 hasConcept C207001950 @default.
• W2585774804 hasConcept C2776256026 @default.
• W2585774804 hasConcept C2776415932 @default.
• W2585774804 hasConcept C502942594 @default.
• W2585774804 hasConcept C54355233 @default.
• W2585774804 hasConcept C553184892 @default.
• W2585774804 hasConcept C55493867 @default.
• W2585774804 hasConcept C62112901 @default.
• W2585774804 hasConcept C71924100 @default.
• W2585774804 hasConcept C81885089 @default.
• W2585774804 hasConcept C86803240 @default.
• W2585774804 hasConceptScore W2585774804C104317684 @default.

• next