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• W2586054245 abstract "We propose the combination of alkyne-tag and surface-enhanced Raman scattering (SERS) spectroscopy to performhighly-sensitive and selective drug imaging in live cells. Gold nanoparticles are introduced in lysosomes throughendocytosis as SERS agents, and the alkyne-tagged drugs are subsequently administered in cells. Raman microscopicobservation reveals the arrival of drug in lysosome through enhanced Raman signal of alkyne. Since the peak of alkyneappears in Raman-silent region of biomolecules, selective detection of drugs is possible without background signal ofendogenous molecules. From endocytosed gold nanoparticles in living HeLa cells, we observed distinct Raman signalfrom alkyne-tagged inhibitor of lysosomal enzyme." @default.
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• W2586054245 date "2017-02-09" @default.
• W2586054245 modified "2023-09-23" @default.
• W2586054245 title "Surface-enhanced Raman scattering (SERS) imaging of alkyne-tagged small molecule drug in live cells with endocytosed gold nanoparticles" @default.
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• W2586054245 doi "https://doi.org/10.1117/12.2256126" @default.
• W2586054245 hasPublicationYear "2017" @default.
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