Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586106736> ?p ?o ?g. }
- W2586106736 endingPage "78" @default.
- W2586106736 startingPage "67" @default.
- W2586106736 abstract "Skeletal muscle is the most abundant tissue in the human body and can adapt its mass as a consequence of physical activity, metabolism, growth factors, and disease conditions. Skeletal muscle contains an extensive network of endoplasmic reticulum (ER), called sarcoplasmic reticulum, which plays an important role in the regulation of proteostasis and calcium homeostasis. In many cell types, environmental and genetic factors that disrupt ER function cause an accumulation of misfolded and unfolded proteins in the ER lumen that ultimately leads to ER stress. To alleviate the stress and restore homeostasis, the ER activates a signaling network called the unfolded protein response (UPR). The UPR has three arms, which regulate protein synthesis and expression of many ER chaperone and regulatory proteins. However, the role of individual UPR pathways in skeletal muscle has just begun to be investigated. Recent studies suggest that UPR pathways play pivotal roles in muscle stem cell homeostasis, myogenic differentiation, and regeneration of injured skeletal muscle. Moreover, markers of ER stress and the UPR are activated in skeletal muscle in diverse conditions such as exercise, denervation, starvation, high fat diet, cancer cachexia, and aging. Accumulating evidence also suggests that ER stress may have important roles in the pathogenesis of inflammatory myopathies and genetic muscle disorders. The purpose of this review article is to discuss the role and potential mechanisms by which ER stress and the individual arms of the UPR regulate skeletal muscle formation, plasticity, and function in various physiological and pathophysiological conditions." @default.
- W2586106736 created "2017-02-17" @default.
- W2586106736 creator A5074350735 @default.
- W2586106736 creator A5079130680 @default.
- W2586106736 creator A5083167569 @default.
- W2586106736 date "2017-05-16" @default.
- W2586106736 modified "2023-10-14" @default.
- W2586106736 title "Emerging roles of ER stress and unfolded protein response pathways in skeletal muscle health and disease" @default.
- W2586106736 cites W1481314844 @default.
- W2586106736 cites W1521170528 @default.
- W2586106736 cites W154756152 @default.
- W2586106736 cites W1603706308 @default.
- W2586106736 cites W1670138443 @default.
- W2586106736 cites W1778165142 @default.
- W2586106736 cites W178670659 @default.
- W2586106736 cites W1963622453 @default.
- W2586106736 cites W1967883750 @default.
- W2586106736 cites W1968973215 @default.
- W2586106736 cites W1974719515 @default.
- W2586106736 cites W1980195461 @default.
- W2586106736 cites W1981515291 @default.
- W2586106736 cites W1989181950 @default.
- W2586106736 cites W1990005561 @default.
- W2586106736 cites W1990786422 @default.
- W2586106736 cites W1990922228 @default.
- W2586106736 cites W1993305863 @default.
- W2586106736 cites W1995004764 @default.
- W2586106736 cites W1997672049 @default.
- W2586106736 cites W1998626286 @default.
- W2586106736 cites W1999203943 @default.
- W2586106736 cites W2007078899 @default.
- W2586106736 cites W2007954304 @default.
- W2586106736 cites W2012483237 @default.
- W2586106736 cites W2017075649 @default.
- W2586106736 cites W2017472601 @default.
- W2586106736 cites W2018766190 @default.
- W2586106736 cites W2020444654 @default.
- W2586106736 cites W2020958481 @default.
- W2586106736 cites W2023465240 @default.
- W2586106736 cites W2023613811 @default.
- W2586106736 cites W2025139842 @default.
- W2586106736 cites W2028279477 @default.
- W2586106736 cites W2033104974 @default.
- W2586106736 cites W2033797333 @default.
- W2586106736 cites W2036145275 @default.
- W2586106736 cites W2036787961 @default.
- W2586106736 cites W2043123806 @default.
- W2586106736 cites W2044304619 @default.
- W2586106736 cites W2046286320 @default.
- W2586106736 cites W2048456744 @default.
- W2586106736 cites W2048509129 @default.
- W2586106736 cites W2051706870 @default.
- W2586106736 cites W2052991849 @default.
- W2586106736 cites W2053765200 @default.
- W2586106736 cites W2056878120 @default.
- W2586106736 cites W2059083151 @default.
- W2586106736 cites W2059895383 @default.
- W2586106736 cites W2065056367 @default.
- W2586106736 cites W2068335749 @default.
- W2586106736 cites W2072335655 @default.
- W2586106736 cites W2072437327 @default.
- W2586106736 cites W2076496758 @default.
- W2586106736 cites W2078001940 @default.
- W2586106736 cites W2078044922 @default.
- W2586106736 cites W2079566767 @default.
- W2586106736 cites W2083542905 @default.
- W2586106736 cites W2086102771 @default.
- W2586106736 cites W2089198803 @default.
- W2586106736 cites W2100178504 @default.
- W2586106736 cites W2103274097 @default.
- W2586106736 cites W2106324494 @default.
- W2586106736 cites W2107045511 @default.
- W2586106736 cites W2107887017 @default.
- W2586106736 cites W2108470822 @default.
- W2586106736 cites W2109340122 @default.
- W2586106736 cites W2112989439 @default.
- W2586106736 cites W2114063620 @default.
- W2586106736 cites W2118337893 @default.
- W2586106736 cites W2120736516 @default.
- W2586106736 cites W2125366681 @default.
- W2586106736 cites W2129418510 @default.
- W2586106736 cites W2130053803 @default.
- W2586106736 cites W2130062788 @default.
- W2586106736 cites W2131140036 @default.
- W2586106736 cites W2132371718 @default.
- W2586106736 cites W2137859531 @default.
- W2586106736 cites W2143113982 @default.
- W2586106736 cites W2144065739 @default.
- W2586106736 cites W2144203293 @default.
- W2586106736 cites W2144794300 @default.
- W2586106736 cites W2146027431 @default.
- W2586106736 cites W2147260787 @default.
- W2586106736 cites W2148527632 @default.
- W2586106736 cites W2149927906 @default.
- W2586106736 cites W2153217835 @default.
- W2586106736 cites W2154584639 @default.
- W2586106736 cites W2154803724 @default.
- W2586106736 cites W2156131965 @default.