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- W2586145954 abstract "ThepH optimum was between 6.5and 8.0, andafter 2minofincubation mostoftheradioactivity wasfound inthedeoxyribonucleic acid(DNA)fraction. lodoacetate ataconcentration of10-2 M caused a 50%inhibition ofuptake. Preincubation ofresting cellsfor10minwithfolinate (10-13A mole/ml) diminished the3H-thymidine uptake by75%.Ingrowing cells, the folinate-induced inhibition was still more striking. Deoxyuridine augmented the folinate effect, whereas fluorodeoxyuridine andaminopterin or amethopterin abolished it. Preincubation withfolinate didnotinterfere withtheuptake of3Hamethopterin, andthustheinhibitor didnotcompeteforuptake sites within the cell. Theroleofthese inhibitors inreversing thefolinate effect isdiscussed. Cells preincubated withfolinate showed an increased incorporation of14C-uracil into DNA,presumably after prior conversion tothymidylate. We concluded that the folinate effect wasduetostimulation ofdenovothymidylate synthesis with concomitant inhibition oftheuptake ofexternal thymidine. Pediococcus cerevisiae ATCC 8081 (Leuconostoc citrovorum) responds quantitatively to 5-formyltetrahydro pteroylglutamate (5-HCO" @default.
- W2586145954 created "2017-02-17" @default.
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- W2586145954 date "1968-01-01" @default.
- W2586145954 modified "2023-09-27" @default.
- W2586145954 title "Effect ofFolinate on Thymidine Uptakeby Pediococcus cerevisiae" @default.
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