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- W2586156640 abstract "In this paper we provide an overview of the status of various colchicine derivatives in preclinical development with special focus on their anti-cancer activity. We discuss several groups of compounds that have been designed to differentially bind with specific affinities for tubulin β isotypes, especially in regard to βIII, which is commonly over-expressed in cancer. Computational prediction, protein-based and cell-based assays are summarized as well as some animal tests conducted on these compounds. It is concluded that an untapped potential exists for exploiting the colchicine scaffold as a pharmacophore with the possibility of increasing its affinity for tubulin isotypes overexpressed in cancer and decreasing it for normal cells thereby widening the therapeutic window." @default.
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- W2586156640 date "2017-07-26" @default.
- W2586156640 modified "2023-09-24" @default.
- W2586156640 title "Novel Colchicine Derivatives and their Anti-cancer Activity" @default.
- W2586156640 doi "https://doi.org/10.2174/1568026617666170104143618" @default.
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