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• W2586171921 endingPage "1370" @default.
• W2586171921 startingPage "1364" @default.
• W2586171921 abstract "In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent, OX2R-selective molecule that exhibited a promising in vivo profile. Further structural modification led to an unexpected restoration of OX1R antagonism. Herein, these changes are discussed and a rationale for selectivity based on computational modeling is proposed." @default.
• W2586171921 created "2017-02-17" @default.
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• W2586171921 date "2017-03-01" @default.
• W2586171921 modified "2023-09-27" @default.
• W2586171921 title "Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists" @default.
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• W2586171921 doi "https://doi.org/10.1016/j.bmcl.2017.02.012" @default.
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