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• W2586186137 abstract "504 Objectives: While 18F-FDG PET can measure the metabolic activity of tumors and has been shown useful to assess the response to therapy, dynamic contrast enhanced MRI (DCE-MRI) can show corresponding alterations in tumor perfusion and vascular permeability. This study was performed to correlate changes in metabolic activity and perfusion in response to therapy using multi-modality imaging with small animal PET and MRI. Methods: PET and MRI were used to monitor treatment response with doxorubicin of Balb/c mice bearing breast tumors (MC7-L1 and MC4-L2). Imaging and treatment began on day 0, which was 4 weeks after subcutaneous inoculation of 107 cancer cells. Chemotherapy with doxorubicin (7.5 µg/g) was administrated immediately after the PET scan on day 0 and 7. The animals were scanned on day 0, 1, 7 and 14 with MRI, immediately followed by 18F-FDG PET, using a Varian 7T animal scanner for MRI and the Sherbrooke avalanche photodiode animal PET scanner. Adequate fusion of the sequential MRI and PET scans was achieved by using the same molded bed featuring 3 separate 20-µL markers of Gd-DTPA and 18F-FDG. Gd-DTPA was injected to evaluate the tumor vessel permeability for MRI. 750 µCi of 18F-FDG was injected for the whole-body PET scan. Image fusion was performed with an in-house registration software using mutual information maximization. The fiducial markers served to assess the performance of the registration algorithm. Results: Concurrent imaging and fusion of perfusion and metabolism data allow more comprehensive assessment of tumor behavior during chemotherapy. In control mice, tumor progression with variable degree of necrosis was observed. The tumor uptake of 18F-FDG drastically increased in the control group compared to the treated group on days 7 and 14. Meanwhile, a drastic decrease in perfusion was observed between days 7 and 14, with necrosis appearing both in the core and at the periphery of the tumors. In treated mice, the tumor 18F-FDG uptake showed a small increase on day 7, and then either stabilized or weakly increased at day 14, but to a much lower degree than untreated animals. Tumor size and perfusion, however, was observed to remain low throughout the protocol. Conclusions: Whole-body MRI and 18F-FDG PET fusion imaging allows tracking changes in the microcirculation and metabolic activity of tumors during doxorubicin treatment and provided information that was not available by either one of the techniques taken separately. Research Support (if any): Canadian Institutes of Health Research Canadian Breast Cancer Research Alliance" @default.
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• W2586186137 date "2006-05-01" @default.
• W2586186137 modified "2023-09-23" @default.
• W2586186137 title "PET/MRI fusion imaging in the follow-up of glucose metabolism and perfusion in tumors after chemotherapy in a murine model of breast cancer" @default.
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