FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586187977> ?p ?o ?g. }

• W2586187977 endingPage "2051" @default.
• W2586187977 startingPage "2033" @default.
• W2586187977 abstract "Antimicrobial resistance in bacteria is becoming increasingly prevalent, posing a critical challenge to global health. Bacterial biofilm formation is a common resistance mechanism that reduces the effectiveness of antibiotics. Thus, the development of compounds that can disrupt bacterial biofilms is a potential strategy to combat antimicrobial resistance. We report herein the synthesis of amphipathic guanidine-embedded glyoxamide-based peptidomimetics via ring-opening reactions of N-naphthoylisatins with amines and amino acids. These compounds were investigated for their antibacterial activity by the determination of minimum inhibitory concentration (MIC) against S. aureus and E. coli. Compounds 35, 36, and 66 exhibited MIC values of 6, 8 and 10 μg mL-1 against S. aureus, respectively, while compounds 55 and 56 showed MIC values of 17 and 19 μg mL-1 against E. coli, respectively. Biofilm disruption and inhibition activities were also evaluated against various Gram-positive and Gram-negative bacteria. The most active compound 65 exhibited the greatest disruption of established biofilms by 65% in S. aureus, 61% in P. aeruginosa, and 60% in S. marcescens respectively, at 250 μM concentration, while compound 52 inhibited the formation of biofilms by 72% in S. marcescens at 250 μM. We also report here the in vitro toxicity against MRC-5 human lung fibroblast cells. Finally, the pore forming capability of the three most potent compounds were tested using tethered bilayer lipid membrane (tBLM) technology." @default.
• W2586187977 created "2017-02-17" @default.
• W2586187977 creator A5001869190 @default.
• W2586187977 creator A5014810249 @default.
• W2586187977 creator A5014947771 @default.
• W2586187977 creator A5017276071 @default.
• W2586187977 creator A5049789322 @default.
• W2586187977 creator A5054628624 @default.
• W2586187977 creator A5055473438 @default.
• W2586187977 creator A5072061463 @default.
• W2586187977 creator A5073465676 @default.
• W2586187977 creator A5090646012 @default.
• W2586187977 date "2017-01-01" @default.
• W2586187977 modified "2023-09-26" @default.
• W2586187977 title "Amphipathic guanidine-embedded glyoxamide-based peptidomimetics as novel antibacterial agents and biofilm disruptors" @default.
• W2586187977 cites W1509291382 @default.
• W2586187977 cites W1645293564 @default.
• W2586187977 cites W1969383148 @default.
• W2586187977 cites W1975128800 @default.
• W2586187977 cites W1992172334 @default.
• W2586187977 cites W1993906884 @default.
• W2586187977 cites W1998002492 @default.
• W2586187977 cites W2000524815 @default.
• W2586187977 cites W2003144417 @default.
• W2586187977 cites W2015271074 @default.
• W2586187977 cites W2015481485 @default.
• W2586187977 cites W2042790122 @default.
• W2586187977 cites W2046704370 @default.
• W2586187977 cites W2049276478 @default.
• W2586187977 cites W2055613435 @default.
• W2586187977 cites W2066271990 @default.
• W2586187977 cites W2076797055 @default.
• W2586187977 cites W2079531326 @default.
• W2586187977 cites W2087125825 @default.
• W2586187977 cites W2088326978 @default.
• W2586187977 cites W2091821114 @default.
• W2586187977 cites W2100266303 @default.
• W2586187977 cites W2113657296 @default.
• W2586187977 cites W2115486016 @default.
• W2586187977 cites W2115933619 @default.
• W2586187977 cites W2119567467 @default.
• W2586187977 cites W2122836009 @default.
• W2586187977 cites W2125603952 @default.
• W2586187977 cites W2133217042 @default.
• W2586187977 cites W2138218836 @default.
• W2586187977 cites W2144440398 @default.
• W2586187977 cites W2150188019 @default.
• W2586187977 cites W2154385453 @default.
• W2586187977 cites W2156164665 @default.
• W2586187977 cites W2159051700 @default.
• W2586187977 cites W2171050239 @default.
• W2586187977 cites W2258769416 @default.
• W2586187977 cites W2290750088 @default.
• W2586187977 cites W2294452616 @default.
• W2586187977 cites W2315594095 @default.
• W2586187977 cites W2321111614 @default.
• W2586187977 cites W2325761006 @default.
• W2586187977 cites W2493999360 @default.
• W2586187977 cites W4210968711 @default.
• W2586187977 cites W4238374804 @default.
• W2586187977 doi "https://doi.org/10.1039/c7ob00053g" @default.
• W2586187977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28203673" @default.
• W2586187977 hasPublicationYear "2017" @default.
• W2586187977 type Work @default.
• W2586187977 sameAs 2586187977 @default.
• W2586187977 citedByCount "20" @default.
• W2586187977 countsByYear W25861879772017 @default.
• W2586187977 countsByYear W25861879772018 @default.
• W2586187977 countsByYear W25861879772019 @default.
• W2586187977 countsByYear W25861879772020 @default.
• W2586187977 countsByYear W25861879772021 @default.
• W2586187977 countsByYear W25861879772022 @default.
• W2586187977 countsByYear W25861879772023 @default.
• W2586187977 crossrefType "journal-article" @default.
• W2586187977 hasAuthorship W2586187977A5001869190 @default.
• W2586187977 hasAuthorship W2586187977A5014810249 @default.
• W2586187977 hasAuthorship W2586187977A5014947771 @default.
• W2586187977 hasAuthorship W2586187977A5017276071 @default.
• W2586187977 hasAuthorship W2586187977A5049789322 @default.
• W2586187977 hasAuthorship W2586187977A5054628624 @default.
• W2586187977 hasAuthorship W2586187977A5055473438 @default.
• W2586187977 hasAuthorship W2586187977A5072061463 @default.
• W2586187977 hasAuthorship W2586187977A5073465676 @default.
• W2586187977 hasAuthorship W2586187977A5090646012 @default.
• W2586187977 hasBestOaLocation W25861879772 @default.
• W2586187977 hasConcept C124790011 @default.
• W2586187977 hasConcept C15920480 @default.
• W2586187977 hasConcept C176947019 @default.
• W2586187977 hasConcept C178790620 @default.
• W2586187977 hasConcept C185592680 @default.
• W2586187977 hasConcept C202751555 @default.
• W2586187977 hasConcept C21951064 @default.
• W2586187977 hasConcept C26381139 @default.
• W2586187977 hasConcept C2779281246 @default.
• W2586187977 hasConcept C2779463914 @default.
• W2586187977 hasConcept C2780104969 @default.
• W2586187977 hasConcept C4937899 @default.
• W2586187977 hasConcept C501593827 @default.

• next