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• W2586192699 abstract "The plasma membrane (PM) is frequently challenged by mechanical stresses. In budding yeast, TORC2-Ypk1/Ypk2 kinase cascade plays a critical role in PM stress responses by reorganizing the actin cytoskeleton via Rho1 GTPase. However, the molecular mechanism by which TORC2-Ypk1/Ypk2 regulates Rho1 is not well defined. Here, we found that Ypk1/Ypk2 maintain PM localization of Rho1 under PM stress via spatial reorganization of the lipids including phosphatidylserine (PS). Genetic evidence suggests that this process is mediated by the Lem3-containing lipid flippase. We propose that TORC2-Ypk1/Ypk2-Lem3 axis-mediated lipid remodelling is a backup mechanism for PM anchoring of Rho1 after PM stress-induced acute degradation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), which is responsible for Rho1 localization in a normal condition. Since all the signaling molecules studied here are conserved in higher eukaryotes, our findings may represent a general mechanism to cope with PM stress." @default.
• W2586192699 created "2017-02-17" @default.
• W2586192699 creator A5032990510 @default.
• W2586192699 creator A5053883638 @default.
• W2586192699 creator A5084170135 @default.
• W2586192699 date "2017-01-01" @default.
• W2586192699 modified "2023-10-17" @default.
• W2586192699 title "Ypk1/Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodelling after membrane stresses" @default.
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• W2586192699 doi "https://doi.org/10.1242/jcs.198382" @default.
• W2586192699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28167678" @default.
• W2586192699 hasPublicationYear "2017" @default.
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