Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586232176> ?p ?o ?g. }
- W2586232176 endingPage "1303" @default.
- W2586232176 startingPage "1295" @default.
- W2586232176 abstract "Abstract Osteoarthritis, the most prevalent form of joint disease, afflicts 9% of the U.S. population over the age of 30 and costs the economy nearly $100 billion annually in healthcare and socioeconomic costs. It is characterized by joint pain and dysfunction, though the pathophysiology remains largely unknown. Due to its avascular nature and limited cellularity, articular cartilage exhibits a poor intrinsic healing response following injury. As such, significant research efforts are aimed at producing engineered cartilage as a cell-based approach for articular cartilage repair. However, the knee joint is mechanically demanding, and during injury, also a milieu of harsh inflammatory agents. The unforgiving mechano-chemical environment requires tissue replacements that are capable of bearing such burdens. The use of mesenchymal stem cells (MSCs) for cartilage tissue engineering has emerged as a promising cell source due to their ease of isolation, capacity to readily expand in culture, and ability to undergo lineage-specific differentiation into chondrocytes. However, to date, very few studies utilizing MSCs have successfully recapitulated the structural and functional properties of native cartilage, exposing the difficult process of uniformly differentiating stem cells into desired cell fates and maintaining the phenotype during in vitro culture and after in vivo implantation. To address these shortcomings, here, we present a concise review on modulating stem cell behavior, tissue development and function using well-developed techniques from chondrocyte-based cartilage tissue engineering." @default.
- W2586232176 created "2017-02-17" @default.
- W2586232176 creator A5010048130 @default.
- W2586232176 creator A5041941139 @default.
- W2586232176 date "2017-02-08" @default.
- W2586232176 modified "2023-09-23" @default.
- W2586232176 title "Concise Review: Mesenchymal Stem Cells for Functional Cartilage Tissue Engineering: Taking Cues from Chondrocyte-Based Constructs" @default.
- W2586232176 cites W1153661258 @default.
- W2586232176 cites W116630109 @default.
- W2586232176 cites W1505171679 @default.
- W2586232176 cites W1556212925 @default.
- W2586232176 cites W1701342 @default.
- W2586232176 cites W172058065 @default.
- W2586232176 cites W178753903 @default.
- W2586232176 cites W180655600 @default.
- W2586232176 cites W1844685923 @default.
- W2586232176 cites W1954624720 @default.
- W2586232176 cites W1965380417 @default.
- W2586232176 cites W1965425745 @default.
- W2586232176 cites W1974382774 @default.
- W2586232176 cites W1980336509 @default.
- W2586232176 cites W1984213215 @default.
- W2586232176 cites W1985141962 @default.
- W2586232176 cites W1989739945 @default.
- W2586232176 cites W1989841129 @default.
- W2586232176 cites W1991505634 @default.
- W2586232176 cites W1992598304 @default.
- W2586232176 cites W1992739919 @default.
- W2586232176 cites W1995122819 @default.
- W2586232176 cites W1995499476 @default.
- W2586232176 cites W1995527685 @default.
- W2586232176 cites W1997614695 @default.
- W2586232176 cites W1998019270 @default.
- W2586232176 cites W2000326580 @default.
- W2586232176 cites W2002100798 @default.
- W2586232176 cites W2004290723 @default.
- W2586232176 cites W2004724795 @default.
- W2586232176 cites W2007089071 @default.
- W2586232176 cites W2007098561 @default.
- W2586232176 cites W2007469598 @default.
- W2586232176 cites W2008750339 @default.
- W2586232176 cites W2010868069 @default.
- W2586232176 cites W2011409357 @default.
- W2586232176 cites W2012044194 @default.
- W2586232176 cites W2013674234 @default.
- W2586232176 cites W2016936906 @default.
- W2586232176 cites W2018648995 @default.
- W2586232176 cites W2020342708 @default.
- W2586232176 cites W2022229181 @default.
- W2586232176 cites W2023436570 @default.
- W2586232176 cites W2024452130 @default.
- W2586232176 cites W2025371271 @default.
- W2586232176 cites W2026406517 @default.
- W2586232176 cites W2029621921 @default.
- W2586232176 cites W2029782351 @default.
- W2586232176 cites W2032645821 @default.
- W2586232176 cites W2032936734 @default.
- W2586232176 cites W2037715918 @default.
- W2586232176 cites W2040471298 @default.
- W2586232176 cites W2044011855 @default.
- W2586232176 cites W2044685047 @default.
- W2586232176 cites W2045412227 @default.
- W2586232176 cites W2048127687 @default.
- W2586232176 cites W2050273631 @default.
- W2586232176 cites W2051733665 @default.
- W2586232176 cites W2054274983 @default.
- W2586232176 cites W2056723985 @default.
- W2586232176 cites W2056951922 @default.
- W2586232176 cites W2058504739 @default.
- W2586232176 cites W2060778212 @default.
- W2586232176 cites W2064990766 @default.
- W2586232176 cites W2067662578 @default.
- W2586232176 cites W2067716147 @default.
- W2586232176 cites W2068667239 @default.
- W2586232176 cites W2069165747 @default.
- W2586232176 cites W2073759660 @default.
- W2586232176 cites W2074800593 @default.
- W2586232176 cites W2076318547 @default.
- W2586232176 cites W2077946417 @default.
- W2586232176 cites W2079082206 @default.
- W2586232176 cites W2082361489 @default.
- W2586232176 cites W2083810223 @default.
- W2586232176 cites W2087810821 @default.
- W2586232176 cites W2090183574 @default.
- W2586232176 cites W2090851652 @default.
- W2586232176 cites W2091408108 @default.
- W2586232176 cites W2095698925 @default.
- W2586232176 cites W2099315762 @default.
- W2586232176 cites W2099765735 @default.
- W2586232176 cites W2101702091 @default.
- W2586232176 cites W2108927236 @default.
- W2586232176 cites W2113434515 @default.
- W2586232176 cites W2114241729 @default.
- W2586232176 cites W2116753809 @default.
- W2586232176 cites W2118470612 @default.
- W2586232176 cites W2118700761 @default.
- W2586232176 cites W2119882428 @default.
- W2586232176 cites W2120616795 @default.