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- W2586285237 abstract "The enthusiasm of the clinical cancer research community has been renewed by clinically relevant demonstrations of molecular profiling arising from “whole genome sequencing” (WGS), leading to novel approaches of “personalised” cancer treatments. However, critics question the merits of such large-scale, expensive, time-consuming, dataharvesting, and descriptive approaches, citing the paucity of improvement in outcomes. We address here the challenges and potentials in the clinical application of whole-genome sequencing for cancer. Why a whole genome sequencing approach to cancer? Cancers ultimately result from the pathological impact of aberrations in DNA sequence. Human anomalous DNA sequences derive from exposure to mutagens, virus, inflammation, and even" @default.
- W2586285237 created "2017-02-17" @default.
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- W2586285237 date "2012-01-01" @default.
- W2586285237 modified "2023-09-27" @default.
- W2586285237 title "The Genome Doctor, a Whole-Genome Sequencing Approach to Cancer" @default.
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- W2586285237 hasPublicationYear "2012" @default.
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