FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586291210> ?p ?o ?g. }

• W2586291210 endingPage "2751" @default.
• W2586291210 startingPage "2744" @default.
• W2586291210 abstract "Urinary stone disease (USD) is increasing in adult and pediatric populations. Adult and pediatric studies have demonstrated decreased bone mineral density and increased fracture rates. USD has also been independently linked to increased rates of myocardial infarction and cerebral vascular accidents. Although USD is a multisystem disorder involving the kidneys, bone, and vasculature, the molecular mechanisms linking these three organs remain unknown. Calcium oxalate nephropathy was induced in C57BL/6J mice with intra-peritoneal (ip) injection of sodium glyoxolate. Half of each kidney underwent Pizzalato staining and half was snap frozen for RNA extraction. RT2 Profiler Mouse Atherosclerosis, Osteoporosis, and Calcium Signaling PCR Arrays (Qiagen) were performed. Only results that passed quality checks in PCR array reproducibility and genomic DNA contamination were included. Genes had to show at least fourfold differential expression and P < 0.01 to be considered significant. Atherosclerosis array showed upregulation of 19 genes by fourfold, 10 of which were ≥10-fold. All 19 had P ≤ 0.002. The Osteoporosis array showed fourfold upregulation of 10 genes, five showed >10-fold increase. All 10 have P ≤ 0.003. The calcium signaling array showed significant fourfold upregulation of 10 genes, four of which were ≥10-fold. All 10 have P ≤ 0.03. We have demonstrated that calcium oxalate nephropathy can induce upregulation of atherosclerotic, metabolic bone, and calcium homeostasis genes in a murine model. This may be and initial step in identifying the molecular mechanisms linking stone, bone, and cardiovascular disease. J. Cell. Biochem. 118: 2744–2751, 2017. © 2017 Wiley Periodicals, Inc." @default.
• W2586291210 created "2017-02-17" @default.
• W2586291210 creator A5002189418 @default.
• W2586291210 creator A5025832883 @default.
• W2586291210 creator A5033911494 @default.
• W2586291210 creator A5041834556 @default.
• W2586291210 creator A5063044772 @default.
• W2586291210 date "2017-04-25" @default.
• W2586291210 modified "2023-09-26" @default.
• W2586291210 title "Renal Calcium Oxalate Deposits Induce a Pro-Atherosclerotic and Pro-Osteoporotic Response in Mice" @default.
• W2586291210 cites W1516434930 @default.
• W2586291210 cites W1855737037 @default.
• W2586291210 cites W1967039869 @default.
• W2586291210 cites W1973260917 @default.
• W2586291210 cites W1975553632 @default.
• W2586291210 cites W1984911288 @default.
• W2586291210 cites W1990526837 @default.
• W2586291210 cites W1992121180 @default.
• W2586291210 cites W1997609074 @default.
• W2586291210 cites W2000647744 @default.
• W2586291210 cites W2001271520 @default.
• W2586291210 cites W2002857893 @default.
• W2586291210 cites W2003793255 @default.
• W2586291210 cites W2015414907 @default.
• W2586291210 cites W2017551024 @default.
• W2586291210 cites W2020245957 @default.
• W2586291210 cites W2020780927 @default.
• W2586291210 cites W2033538734 @default.
• W2586291210 cites W2043033796 @default.
• W2586291210 cites W2044908713 @default.
• W2586291210 cites W2053910616 @default.
• W2586291210 cites W2057270824 @default.
• W2586291210 cites W2070370833 @default.
• W2586291210 cites W2072262871 @default.
• W2586291210 cites W2072329780 @default.
• W2586291210 cites W2075778279 @default.
• W2586291210 cites W2076649502 @default.
• W2586291210 cites W2076743215 @default.
• W2586291210 cites W2084917522 @default.
• W2586291210 cites W2094629035 @default.
• W2586291210 cites W2101444839 @default.
• W2586291210 cites W2106094542 @default.
• W2586291210 cites W2111848041 @default.
• W2586291210 cites W2127963975 @default.
• W2586291210 cites W2129651548 @default.
• W2586291210 cites W2147737790 @default.
• W2586291210 cites W2153498084 @default.
• W2586291210 cites W2156593520 @default.
• W2586291210 cites W2157672617 @default.
• W2586291210 cites W2161706310 @default.
• W2586291210 cites W2167086986 @default.
• W2586291210 cites W2167835756 @default.
• W2586291210 cites W2169758044 @default.
• W2586291210 cites W2170034821 @default.
• W2586291210 cites W2171942415 @default.
• W2586291210 doi "https://doi.org/10.1002/jcb.25924" @default.
• W2586291210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28176358" @default.
• W2586291210 hasPublicationYear "2017" @default.
• W2586291210 type Work @default.
• W2586291210 sameAs 2586291210 @default.
• W2586291210 citedByCount "2" @default.
• W2586291210 countsByYear W25862912102020 @default.
• W2586291210 countsByYear W25862912102021 @default.
• W2586291210 crossrefType "journal-article" @default.
• W2586291210 hasAuthorship W2586291210A5002189418 @default.
• W2586291210 hasAuthorship W2586291210A5025832883 @default.
• W2586291210 hasAuthorship W2586291210A5033911494 @default.
• W2586291210 hasAuthorship W2586291210A5041834556 @default.
• W2586291210 hasAuthorship W2586291210A5063044772 @default.
• W2586291210 hasConcept C104317684 @default.
• W2586291210 hasConcept C126322002 @default.
• W2586291210 hasConcept C127561419 @default.
• W2586291210 hasConcept C134018914 @default.
• W2586291210 hasConcept C2776179656 @default.
• W2586291210 hasConcept C2776541429 @default.
• W2586291210 hasConcept C2780091579 @default.
• W2586291210 hasConcept C519063684 @default.
• W2586291210 hasConcept C55493867 @default.
• W2586291210 hasConcept C71924100 @default.
• W2586291210 hasConcept C86803240 @default.
• W2586291210 hasConcept C87975464 @default.
• W2586291210 hasConceptScore W2586291210C104317684 @default.
• W2586291210 hasConceptScore W2586291210C126322002 @default.
• W2586291210 hasConceptScore W2586291210C127561419 @default.
• W2586291210 hasConceptScore W2586291210C134018914 @default.
• W2586291210 hasConceptScore W2586291210C2776179656 @default.
• W2586291210 hasConceptScore W2586291210C2776541429 @default.
• W2586291210 hasConceptScore W2586291210C2780091579 @default.
• W2586291210 hasConceptScore W2586291210C519063684 @default.
• W2586291210 hasConceptScore W2586291210C55493867 @default.
• W2586291210 hasConceptScore W2586291210C71924100 @default.
• W2586291210 hasConceptScore W2586291210C86803240 @default.
• W2586291210 hasConceptScore W2586291210C87975464 @default.
• W2586291210 hasIssue "9" @default.
• W2586291210 hasLocation W25862912101 @default.
• W2586291210 hasLocation W25862912102 @default.
• W2586291210 hasOpenAccess W2586291210 @default.
• W2586291210 hasPrimaryLocation W25862912101 @default.

• next