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• W2586292647 endingPage "203" @default.
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• W2586292647 abstract "Interneuronal pathology is implicated in many neuropsychiatric disorders, including autism spectrum disorder (ASD) and Tourette syndrome (TS). Interneurons of the striatum, including the parvalbumin-expressing fast-spiking interneurons (FSIs) and the large cholinergic interneurons (CINs), are affected in patients with TS and in preclinical models of both ASD and TS.To test the causal importance of these neuronal abnormalities, we recapitulated them in vivo in developmentally normal mice using a combination transgenic-viral strategy for targeted toxin-mediated ablation.We found that conjoint ~50% depletion of FSIs and CINs in the dorsal striatum of male mice produces spontaneous stereotypy and marked deficits in social interaction. Strikingly, these behavioral effects are not seen in female mice; because ASD and TS have a marked male predominance, this observation reinforces the potential relevance of the finding to human disease. Neither of these effects is seen when only one or the other interneuronal population is depleted; ablation of both is required. Depletion of FSIs, but not of CINs, also produces anxiety-like behavior, as has been described previously. Behavioral pathology in male mice after conjoint FSI and CIN depletion is accompanied by increases in activity-dependent signaling in the dorsal striatum; these alterations were not observed after disruption of only one interneuron type or in doubly depleted female mice.These data indicate that disruption of CIN and FSI interneurons in the dorsal striatum is sufficient to produce network and behavioral changes of potential relevance to ASD, in a sexually dimorphic manner." @default.
• W2586292647 created "2017-02-17" @default.
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• W2586292647 date "2017-08-01" @default.
• W2586292647 modified "2023-10-05" @default.
• W2586292647 title "Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice" @default.
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• W2586292647 cites W1945406363 @default.
• W2586292647 cites W1963736913 @default.
• W2586292647 cites W1967237555 @default.
• W2586292647 cites W1979822748 @default.
• W2586292647 cites W1980577992 @default.
• W2586292647 cites W1985187126 @default.
• W2586292647 cites W1989973456 @default.
• W2586292647 cites W1991786443 @default.
• W2586292647 cites W1992530750 @default.
• W2586292647 cites W1994498762 @default.
• W2586292647 cites W1994982044 @default.
• W2586292647 cites W1995540460 @default.
• W2586292647 cites W1997632825 @default.
• W2586292647 cites W1999531329 @default.
• W2586292647 cites W2003982930 @default.
• W2586292647 cites W2005555763 @default.
• W2586292647 cites W2009431403 @default.
• W2586292647 cites W2021454300 @default.
• W2586292647 cites W2024508781 @default.
• W2586292647 cites W2025052669 @default.
• W2586292647 cites W2026826561 @default.
• W2586292647 cites W2034220807 @default.
• W2586292647 cites W2037553020 @default.
• W2586292647 cites W2038596292 @default.
• W2586292647 cites W2042123414 @default.
• W2586292647 cites W2048168580 @default.
• W2586292647 cites W2058093953 @default.
• W2586292647 cites W2058693322 @default.
• W2586292647 cites W2060649006 @default.
• W2586292647 cites W2064332273 @default.
• W2586292647 cites W2067592930 @default.
• W2586292647 cites W2076683771 @default.
• W2586292647 cites W2080914771 @default.
• W2586292647 cites W2094939629 @default.
• W2586292647 cites W2096240481 @default.
• W2586292647 cites W2097364496 @default.
• W2586292647 cites W2098277878 @default.
• W2586292647 cites W2099756187 @default.
• W2586292647 cites W2100244818 @default.
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• W2586292647 cites W2110925924 @default.
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• W2586292647 cites W2138006810 @default.
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• W2586292647 cites W2147320841 @default.
• W2586292647 cites W2152248242 @default.
• W2586292647 cites W2155904360 @default.
• W2586292647 cites W2164643225 @default.
• W2586292647 cites W2170362840 @default.
• W2586292647 cites W2178727006 @default.
• W2586292647 cites W2210537348 @default.
• W2586292647 cites W2214456560 @default.
• W2586292647 cites W2273816628 @default.
• W2586292647 cites W2276586942 @default.
• W2586292647 cites W2294392975 @default.
• W2586292647 cites W2296983774 @default.
• W2586292647 cites W2310417648 @default.
• W2586292647 cites W2409936214 @default.
• W2586292647 cites W2461704283 @default.
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• W2586292647 doi "https://doi.org/10.1016/j.biopsych.2017.01.020" @default.
• W2586292647 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5374721" @default.
• W2586292647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28347488" @default.
• W2586292647 hasPublicationYear "2017" @default.
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