FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586360876> ?p ?o ?g. }

• W2586360876 endingPage "748" @default.
• W2586360876 startingPage "744" @default.
• W2586360876 abstract "Sustained exogenous stimulation of a hormone‐specific receptor can affect endogenous hormonal regulation. In this context, little is known about the impact of chronic treatment with glucagon‐like peptide‐1 ( GLP ‐1) agonists on the endogenous GLP ‐1 response. We therefore evaluated the impact of chronic liraglutide therapy on endogenous GLP ‐1 and glucose‐dependent insulinotropic polypeptide ( GIP ) response to an oral glucose challenge. A total of 51 people with type 2 diabetes of 2.6 ± 1.9 years’ duration were randomized to daily subcutaneous liraglutide or placebo injection and followed for 48 weeks, with an oral glucose tolerance test ( OGTT ) every 12 weeks. GLP ‐1 and GIP responses were assessed according to their respective area under the curve ( AUC ) from measurements taken at 0, 30, 60, 90 and 120 minutes during each OGTT . There were no differences in AUC GIP between the groups. By contrast, although fasting GLP ‐1 was unaffected, the liraglutide arm had ~2‐fold higher AUC GLP ‐1 at 12 weeks ( P < .001), 24 weeks ( P < .001), 36 weeks ( P = .03) and 48 weeks ( P = .03), as compared with placebo. Thus, chronic liraglutide therapy induces a previously unrecognized, robust and durable enhancement of the endogenous GLP ‐1 response, highlighting the need for further study of the long‐term effects of incretin mimetics on L ‐cell physiology." @default.
• W2586360876 created "2017-02-17" @default.
• W2586360876 creator A5001176785 @default.
• W2586360876 creator A5026062713 @default.
• W2586360876 creator A5061469784 @default.
• W2586360876 creator A5070607809 @default.
• W2586360876 creator A5090437675 @default.
• W2586360876 date "2017-02-09" @default.
• W2586360876 modified "2023-10-18" @default.
• W2586360876 title "Chronic liraglutide therapy induces an enhanced endogenous glucagon‐like peptide‐1 secretory response in early type 2 diabetes" @default.
• W2586360876 cites W1895210134 @default.
• W2586360876 cites W1910418518 @default.
• W2586360876 cites W1967406107 @default.
• W2586360876 cites W1975591028 @default.
• W2586360876 cites W1977226383 @default.
• W2586360876 cites W2041675392 @default.
• W2586360876 cites W2045272891 @default.
• W2586360876 cites W2048876290 @default.
• W2586360876 cites W2069942402 @default.
• W2586360876 cites W2098655712 @default.
• W2586360876 cites W2113411572 @default.
• W2586360876 cites W2117340025 @default.
• W2586360876 cites W2154517237 @default.
• W2586360876 cites W2158803184 @default.
• W2586360876 cites W2159205789 @default.
• W2586360876 cites W2214858768 @default.
• W2586360876 cites W4231833530 @default.
• W2586360876 doi "https://doi.org/10.1111/dom.12858" @default.
• W2586360876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28181363" @default.
• W2586360876 hasPublicationYear "2017" @default.
• W2586360876 type Work @default.
• W2586360876 sameAs 2586360876 @default.
• W2586360876 citedByCount "10" @default.
• W2586360876 countsByYear W25863608762017 @default.
• W2586360876 countsByYear W25863608762018 @default.
• W2586360876 countsByYear W25863608762019 @default.
• W2586360876 countsByYear W25863608762020 @default.
• W2586360876 countsByYear W25863608762022 @default.
• W2586360876 countsByYear W25863608762023 @default.
• W2586360876 crossrefType "journal-article" @default.
• W2586360876 hasAuthorship W2586360876A5001176785 @default.
• W2586360876 hasAuthorship W2586360876A5026062713 @default.
• W2586360876 hasAuthorship W2586360876A5061469784 @default.
• W2586360876 hasAuthorship W2586360876A5070607809 @default.
• W2586360876 hasAuthorship W2586360876A5090437675 @default.
• W2586360876 hasConcept C126322002 @default.
• W2586360876 hasConcept C134018914 @default.
• W2586360876 hasConcept C142724271 @default.
• W2586360876 hasConcept C151730666 @default.
• W2586360876 hasConcept C16613235 @default.
• W2586360876 hasConcept C204787440 @default.
• W2586360876 hasConcept C27081682 @default.
• W2586360876 hasConcept C2776398474 @default.
• W2586360876 hasConcept C2777180221 @default.
• W2586360876 hasConcept C2778563252 @default.
• W2586360876 hasConcept C2778881409 @default.
• W2586360876 hasConcept C2779343474 @default.
• W2586360876 hasConcept C2781308992 @default.
• W2586360876 hasConcept C555293320 @default.
• W2586360876 hasConcept C71315377 @default.
• W2586360876 hasConcept C71924100 @default.
• W2586360876 hasConcept C76318530 @default.
• W2586360876 hasConcept C86803240 @default.
• W2586360876 hasConceptScore W2586360876C126322002 @default.
• W2586360876 hasConceptScore W2586360876C134018914 @default.
• W2586360876 hasConceptScore W2586360876C142724271 @default.
• W2586360876 hasConceptScore W2586360876C151730666 @default.
• W2586360876 hasConceptScore W2586360876C16613235 @default.
• W2586360876 hasConceptScore W2586360876C204787440 @default.
• W2586360876 hasConceptScore W2586360876C27081682 @default.
• W2586360876 hasConceptScore W2586360876C2776398474 @default.
• W2586360876 hasConceptScore W2586360876C2777180221 @default.
• W2586360876 hasConceptScore W2586360876C2778563252 @default.
• W2586360876 hasConceptScore W2586360876C2778881409 @default.
• W2586360876 hasConceptScore W2586360876C2779343474 @default.
• W2586360876 hasConceptScore W2586360876C2781308992 @default.
• W2586360876 hasConceptScore W2586360876C555293320 @default.
• W2586360876 hasConceptScore W2586360876C71315377 @default.
• W2586360876 hasConceptScore W2586360876C71924100 @default.
• W2586360876 hasConceptScore W2586360876C76318530 @default.
• W2586360876 hasConceptScore W2586360876C86803240 @default.
• W2586360876 hasFunder F4320322436 @default.
• W2586360876 hasIssue "5" @default.
• W2586360876 hasLocation W25863608761 @default.
• W2586360876 hasLocation W25863608762 @default.
• W2586360876 hasOpenAccess W2586360876 @default.
• W2586360876 hasPrimaryLocation W25863608761 @default.
• W2586360876 hasRelatedWork W1802595854 @default.
• W2586360876 hasRelatedWork W1980386056 @default.
• W2586360876 hasRelatedWork W2129449971 @default.
• W2586360876 hasRelatedWork W2510267632 @default.
• W2586360876 hasRelatedWork W2583639096 @default.
• W2586360876 hasRelatedWork W2973796988 @default.
• W2586360876 hasRelatedWork W2977447459 @default.
• W2586360876 hasRelatedWork W3028618248 @default.
• W2586360876 hasRelatedWork W3032587524 @default.
• W2586360876 hasRelatedWork W4223466080 @default.
• W2586360876 hasVolume "19" @default.

• next